Evidence map›Paper›PMID 41473389›Full record

ReviewJournal of immunology research2025

IgE Nonresponders in Basophil Activation Tests: A Narrative Review From Mechanistic Insights to Clinical Implications and Future Directions.

Bernadette Eberlein, Tilo Biedermann

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of immunology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. IgE levels correlate with FcFrontiers in allergy · 2026
    Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Bernadette EberleinDepartment of Dermatology and Allergy Biederstein, School of Medicine and Health, TUM University Hospital Rechts der Isar, Technical University of Munich, Biedersteiner Straße 29, D-80802, Munich, Germany, tum.de.ORCID https://orcid.org/0000-0003-4509-6491
Tilo BiedermannDepartment of Dermatology and Allergy Biederstein, School of Medicine and Health, TUM University Hospital Rechts der Isar, Technical University of Munich, Biedersteiner Straße 29, D-80802, Munich, Germany, tum.de.ORCID https://orcid.org/0000-0002-5352-5105

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has been known for about 50 years that a proportion of human basophils does not release histamine or leukotrienes or upregulates activation markers in response to IgE-dependent stimuli. This group of so-called nonresponders with unresponsive basophils is found in up to 20% of tests conducted. There seems to be no relation to clinical symptoms. The nonresponder status is not defined in a standardized manner, but basophils are often considered nonresponsive if they release less than 5% to 10% of their histamine content or show activation of less than or equal to 10% CD63+ basophils after Fc

Indexed as

Basophil Degranulation TestBasophilsHypersensitivityImmunoglobulin EAnimalsBiomarkersHistamine ReleaseHumansReceptors, IgEsrc-Family KinasesSyk KinaseTetraspanin 30BiomarkersImmunoglobulin Elyn protein-tyrosine kinaseReceptors, IgEsrc-Family KinasesSyk KinaseTetraspanin 30basophil activation testCD203c+ basophilsCD63+ basophilsFcεRI cross-linkinginterleukin-3Lyn proteinnonrespondersSyk protein

Identifiers

PMID41473389
PMCPMC12745180

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.