Evidence map›Paper›PMID 41473353›Full record

ArticleJournal of Alzheimer's disease reports

Interaction of insula and hippocampus in memory dysfunction in Alzheimer's disease.

Michelle M Coleman, Marc W Haut, Camila Vieira Ligo Teixeira, Cierra M Keith, Rashi I Mehta, Holly E Phelps, Patrick Worhunsky, Melanie Ward, Joseph Malone, Mark Miller and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Michelle M ColemanRockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.ORCID https://orcid.org/0009-0009-6814-6616
Marc W HautRockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.
Camila Vieira Ligo TeixeiraRockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.
Cierra M KeithRockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.
Rashi I MehtaRockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.ORCID https://orcid.org/0000-0002-2532-7435
Holly E PhelpsRockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.
Patrick WorhunskyRockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.
Melanie WardRockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.
Joseph MaloneRockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.
Mark MillerRockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.
R Osvaldo NaviaRockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.
Gary D MaranoRockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.
Stephanie PocklRockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.
Nafiisah RajabaleeRockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.ORCID https://orcid.org/0009-0004-5408-0883
William T McCuddyDepartment of Neuropsychology, Barrow Neurological Institute, St Joseph Hospital and Medical Center, Phoenix, AZ, USA.
Pierre-Francois D'HaeseRockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.
Ali RezaiRockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.
Kirk WilhelmsenRockefeller Neuroscience Institute, West Virginia University, Morgantown, WV, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The insula, classically linked with emotion and perception, has recently been associated with memory function in Alzheimer's disease (AD). However, its role in memory remains unclear. This study investigated whether the insula contributes directly to memory consolidation or is indirectly involved in memory-related brain regions. We systematically increased diagnostic specificity in memory-impaired patients to assess the role of the insula in memory. Gyrification of the insula was associated with memory consolidation in Aβ+ individuals, only in combination with hippocampal atrophy. These findings suggest insular atrophy interacts with degeneration of the hippocampus in memory dysfunction in AD, but not necessarily in other pathologies.

Indexed as

Alzheimer's diseaseamyloid-βgyrificationinsulamemory

Identifiers

PMID41473353
PMCPMC12745511

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.