Evidence map›Paper›PMID 41473342›Full record

ArticleACS applied nano materials2025

Enhancing Optical Coherence Tomography Contrast of Corneal Stromal Stem Cells Using Gold Nanobipyramids.

Li Jiang, Mai S Rashwan, Wei Sun, Tao Hu, David Myung, Jeffrey L Goldberg, Fang Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS applied nano materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Li JiangSpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Mai S RashwanDepartment of Pharmacology, Case Western Reserve, Cleveland, OH, USA.
Wei SunDepartment of Pharmacology, Case Western Reserve, Cleveland, OH, USA.
Tao HuDepartment of Pharmacology, Case Western Reserve, Cleveland, OH, USA.
David MyungSpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Jeffrey L GoldbergSpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.
Fang ChenSpencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, Palo Alto, CA, USA.

Funding

TISSUE CULTURE AND HYBRIDOMA MODULEP30EY011373 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Irina A Pikuleva · 1997 to 2026
$17.7M
Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0M
Nanoparticle-Based Tracking of Retinal Ganglion Cell TransplantR00EY034168 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Fang Chen · 2025 to 2026
$498k
Nanoparticle-Based Tracking of Retinal Ganglion Cell TransplantK99EY034168 · NEI · STANFORD UNIVERSITY · PI CHEN, FANG · 2023 to 2024
$304k
NEI NIH HHS K99 EY034168NEI NIH HHS P30 EY011373NEI NIH HHS P30 EY026877NEI NIH HHS R00 EY034168
6 · The paper itself

Abstract

Gold nanobipyramids (GNBPs) were investigated as near-infrared contrast agents for optical coherence tomography (OCT) tracking of human corneal stromal stem cells (CSSCs). GNBPs with various longitudinal localized surface plasmon resonance peaks were synthesized, and the variant with a peak at 855 nm (GNBPs-1), closest to the central wavelength of the OCT system, exhibited optimal OCT signal enhancement. To improve stability and biocompatibility, GNBPs-1 were PEGylated.

Indexed as

cell trackingcorneal stromal stem cellcorneal tissue engineeringcorneal wound healinggold nanobipyramidsOCT contrast agents

Identifiers

PMID41473342
PMCPMC12747316

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.