Evidence map›Paper›PMID 41473330›Full record

ArticlebioRxiv : the preprint server for biology2025

Oncogenic and immunomodulatory functions of SUV420H1 in HPV-negative head and neck squamous cell carcinoma.

Arfa Moshiri, Marie Luff, Sohyoung Kim, Meiye Jiang, Mohd Saleem Dar, Malhar Patel, Katherine McKinnon, Elijah F Edmondson, Jawad Akhtar, Hui Cheng and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Arfa MoshiriThoracic and GI Malignancies Branch, National Institutes of Health, Bethesda, MD.
Marie LuffThoracic and GI Malignancies Branch, National Institutes of Health, Bethesda, MD.
Sohyoung KimLaboratory of Receptor Biology and Gene Expression, National Cancer Institute, Bethesda, MD.
Meiye JiangThoracic and GI Malignancies Branch, National Institutes of Health, Bethesda, MD.
Mohd Saleem DarThoracic and GI Malignancies Branch, National Institutes of Health, Bethesda, MD.
Malhar PatelThoracic and GI Malignancies Branch, National Institutes of Health, Bethesda, MD.
Katherine McKinnonCenter for Cancer Research, Office of Science and Technology Resources, Flow Cytometry Core, National Cancer Institute, Bethesda, MD 20892 USA.
Elijah F EdmondsonMolecular Histopathology Laboratory, National Institutes of Health, Frederick, MD.
Jawad AkhtarThoracic and GI Malignancies Branch, National Institutes of Health, Bethesda, MD.
Hui ChengNational Institute of Deafness and Other Communication Disorders, NIH, Bethesda, MD.
Vassiliki SalouraThoracic and GI Malignancies Branch, National Institutes of Health, Bethesda, MD.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite the advent of immunotherapy, human-papilloma-virus (HPV)-negative head and neck squamous cell carcinoma (HNSCC) carries a high morbidity and mortality rate, thus novel therapies are urgently needed. Suppressor Of Variegation 4-20 Homolog 1 (SUV420H1) is a protein lysine methyltransferase that writes H4K20me3. Approximately 35% of HPV-negative HNSCC tumors carry gains/amplifications of

Identifiers

PMID41473330
PMCPMC12747265

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.