Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
14 authors.
Hannes BuckDivision of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-7891-2291
Rodrigo PereyriaDivision of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.
Amika SinglaDivision of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-9454-9111
Qi LiuDivision of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-1732-1209
Daniel A KramerDivision of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-7159-9562
Wan-Ru LeeDepartment of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-2689-5458
Wesley BurfordDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-1407-2895
Jianyi YinDivision of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-1305-5399
Shuai TanDivision of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-4268-6429
Baoyu ChenDivision of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-6366-159X
Luis Sifuentes-DominguezDepartment of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-9525-071X
Neal AltoDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0002-7602-3853
Jen LiouDepartment of Physiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-1546-3115
Ezra BursteinDivision of Digestive and Liver Diseases, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.ORCID 0000-0003-4341-6367
Funding
Type III effector regulation of host signal transduction systemsR01AI083359 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI ALTO, NEAL MATHEW · 2009 to 2024
$6.3M
Regulation of Nutrient Homeostasis by COMMD proteinsR01DK107733 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI DANIEL D BILLADEAU, Ezra Burstein · 2016 to 2026
$4.6M
Signal Integration from Membranes to the Actin CytoskeletonR35GM128786 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI Baoyu Chen · 2018 to 2026
$3.6M
Homeostatic Regulation of PIP2-Calcium SignalingR01GM144479 · NIGMS · UT SOUTHWESTERN MEDICAL CENTER · PI LIOU, JEN · 2022 to 2025
$1.8M
Cholesterol Regulation Through Retriever-Dependent LDL Receptor RecyclingR01HL179813 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Ezra Burstein, Baoyu Chen · 2025 to 2026
$1.4M
The Role of Non-Vesicular Lipid Transport at ER-PM Contact Sites in Phosphoinositide Signaling in Early Dendrite DevelopmentR01NS137605 · NINDS · STATE UNIVERSITY NEW YORK STONY BROOK · PI JEN LIOU, Maya Shelly · 2025 to 2026
$1.3M
TEM for UT Southwestern Electron Microscopy Core FacilityS10OD021685 · OD · UT SOUTHWESTERN MEDICAL CENTER · PI LUBY-PHELPS, KATHERINE J · 2017 to 2017
Phagocytosis, the process by which immune cells ingest and eliminate invading pathogens, is essential for host defense. During this process, phagosomes mature through the recruitment of several effector proteins, such as V-ATPases, proteases, and other enzymes, to effectively degrade the pathogen they contain. These maturation events are thought to be regulated by phosphoinositide transitions, which facilitate phagosome-lysosome fusion. The evolutionarily conserved COMMD/CCDC22/CCDC93 (CCC) complex regulates endosomal recycling and has been identified on phagosomes. Nevertheless, its role in phagosome maturation has not been previously demonstrated. Here, we show that the CCC complex is essential for efficient bacterial clearance by bone marrow-derived macrophages (BMDMs) and the temporal remodeling of phagosomal protein composition. We further reveal that the CCC complex regulates phagosome-lysosome fusion and identify excessive phosphatidylinositol-3-phosphate (PI(3)P) accumulation on phagosome membranes in CCC deficient states, leading to impaired phagosome function. Collectively, our findings uncover a previously unknown role for the CCC complex in innate immune defense.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
The CCC complex directs phagosomal maturation and bactericidal activity in macrophages through PI(3)P regulation. · full record | OpenQuestion