Evidence map›Paper›PMID 41473317›Full record

ArticlebioRxiv : the preprint server for biology2025

Single-cell lineage tracing identifies hemogenic endothelial cells in the adult mouse bone marrow.

Jing-Xin Feng, Mei-Ting Yang, Lili Li, Caiyi C Li, Ferenc Livák, Jack Chen, Yongmei Zhao, Dunrui Wang, Avinash Bhandoola, Naomi Taylor and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Jing-Xin FengLaboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health, Bethesda, MD, 20892, USA.ORCID 0000-0003-0677-2792
Mei-Ting YangSchool of Life Sciences, Northeast Normal University, Changchun, China.
Lili LiLaboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health, Bethesda, MD, 20892, USA.ORCID 0000-0002-6095-3853
Caiyi C LiLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health, Bethesda, MD, 20892, USA.
Ferenc LivákLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health, Bethesda, MD, 20892, USA.
Jack ChenSequencing Facility Bioinformatics Group, Bioinformatics and Computational Science Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA.
Yongmei ZhaoSequencing Facility Bioinformatics Group, Bioinformatics and Computational Science Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, 21702, USA.
Dunrui WangLaboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health, Bethesda, MD, 20892, USA.
Avinash BhandoolaLaboratory of Genome Integrity, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health, Bethesda, MD, 20892, USA.ORCID 0000-0002-4657-8372
Naomi TaylorPediatric Oncology Branch, Center for Cancer Research (CCR), National Cancer Institute (NCI), National Institutes of Health, Bethesda, MD, 20892, USA.
Giovanna TosatoLaboratory of Cellular Oncology, Center for Cancer Research, National Cancer Institute (NCI), National Institutes of Health, Bethesda, MD, 20892, USA.ORCID 0000-0003-1663-3227

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

During mouse development, hematopoietic stem and progenitor cells (HSPC) originate from hemogenic endothelial cells (ECs) through a process of endothelial-to-hematopoietic transition. These HSPC are thought to fully sustain adult hematopoiesis. However, it remains unknown whether adult ECs retain hemogenic potential. Here we used in vivo genetic lineage tracking at population and single-cell (sc) levels, scRNA sequencing, and bone marrow transplantation to detect hemogenic ECs in adult mice. We identify and characterize a small population of bone marrow-resident, adult

Indexed as

bloodCol1a2endothelial cellsendothelial to hemogenic transitionhematopoiesisHematopoietic stem and progenitor cellsmesenchymal cellsRunx1single cell lineage tracingsingle cell RNA sequencing

Identifiers

PMID41473317
PMCPMC12747260

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.