Evidence map›Paper›PMID 41473313›Full record

ArticlebioRxiv : the preprint server for biology2025

Aspartate Transaminases Are Dispensable for Pancreatic Development and Pancreatic Cancer Progression.

Julia Ugras, Noah Nelson, Samuel A Kerk, Damien Sutton, Lin Lin, Peter Sajjakulnukit, Teresa Dombrowski, Gillian Davidson, Brooke Lavoie, Dominik Awad and 10 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Julia UgrasDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Noah NelsonDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Samuel A KerkDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Damien SuttonDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Lin LinDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Peter SajjakulnukitDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Teresa DombrowskiDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Gillian DavidsonDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Brooke LavoieDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Dominik AwadDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0002-7386-2061
Alberto OliveiDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.
Wei YanDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.
Christopher StrayhornDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Megan RadykDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Matthew PerriconeDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Marina Pasca di MaglianoDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-9632-9035
Filip BednarDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-5193-9817
Timothy FrankelDepartment of Surgery, University of Michigan, Ann Arbor, MI, USA.
Yatrik M ShahDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Costas A LyssiotisDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.ORCID 0000-0001-9309-6141

Funding

Training in Basic and Translational Digestive SciencesT32DK094775 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JOHN Y KAO, LINDA C. SAMUELSON · 2012 to 2026
$3.6M
Metabolic Phenotyping in Live Models of Obesity and DiabetesU2CDK135066 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Nathan R. Qi · 2023 to 2026
$3.5M
Intratumoral Metabolic Crosstalk Promotes Therapeutic Resistance in Pancreatic CancerR37CA237421 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Costas Andreas Lyssiotis · 2020 to 2026
$2.6M
Stromal metabolism promotes therapeutic resistance in pancreatic cancerR01CA248160 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LYSSIOTIS, COSTAS ANDREAS · 2020 to 2024
$2.0M
Targeting metabolic stress to induce pancreatic tumor cell deathR01CA244931 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LYSSIOTIS, COSTAS ANDREAS · 2020 to 2024
$1.9M
NCI NIH HHS R01 CA244931NCI NIH HHS R01 CA248160NCI NIH HHS R37 CA237421NIDDK NIH HHS T32 DK094775NIDDK NIH HHS U2C DK135066
6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDA) is the third leading cause of cancer-related deaths in the United States. This is due in part to the limited availability of effective treatment options for patients, highlighting a significant need for new targets and approaches. Deregulated metabolism is a hallmark feature of PDA that has gained attention as a promising inroad for therapy. The aspartate transaminases (glutamate oxaloacetate transaminases, cytosolic GOT1 and mitochondrial GOT2) have several important metabolic functions, including maintaining energy and redox balance and generating aspartate, an essential building block in protein and nucleotide biosynthesis. Previous studies of GOT proteins in preclinical tumor transplant models have yielded conflicting results regarding the requirement of GOT1 and GOT2 for PDA tumor growth. To assess the role of GOT proteins in tumor development and tumor maintenance, we generated conditional knockout mice for

Identifiers

PMID41473313
PMCPMC12746018

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.