Evidence map›Paper›PMID 41473296›Full record

ArticlebioRxiv : the preprint server for biology2025

Ectopic engraftment of nociceptive neurons derived from hPSCs for pain relief and joint homeostasis.

Zhuolun Wang, Weixin Zhang, Ju Wang, Zhiping Wu, Xu Cao, Junmin Peng, Gabsang Lee, Xinzhong Dong

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Zhuolun WangThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Weixin ZhangDepartments of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Ju WangDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Zhiping WuDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Xu CaoDepartments of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, 21205, USA.
Junmin PengDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Gabsang LeeThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Xinzhong DongThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Funding

Systems Approaches to Novel Molecular Mechanism in Alzheimer's DiseaseRF1AG064909 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI PENG, JUNMIN, YU, GANG · 2019 to 2024
$6.4M
Functional Analysis of Mrgpr Family in itch sensationR37NS054791 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Xinzhong Dong · 2022 to 2026
$2.9M
Mechanisms of Varicella Zoster Virus Latency in Human Sensory NeuronsR21AI183368 · NIAID · JOHNS HOPKINS UNIVERSITY · PI VENKATESAN, ARUN · 2024 to 2025
$444k
NIAID NIH HHS R21 AI183368NIA NIH HHS RF1 AG064909NINDS NIH HHS R37 NS054791
6 · The paper itself

Abstract

Chronic pain arises from the interplay of inflammatory signals that activate and sensitize nociceptors within injured tissues. Most analgesics fail clinically due to their mono-targeted mechanisms. Here, we apply human pluripotent stem cell-derived nociceptive neurons (hPSC-NNs) as therapeutic agents for osteoarthritis, targeting both pain and joint degeneration. We generated sensory neurons from hPSCs and identified

Identifiers

PMID41473296
PMCPMC12746131

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.