Evidence map›Paper›PMID 41473286›Full record

ArticlebioRxiv : the preprint server for biology2025

Therapeutic remodeling of the tuberculosis granuloma with 1-methyl-D-tryptophan enhances CD8

Erin F McCaffrey, Alea C Delmastro, Bindu Singh, Annu Devi, Nadia A Golden, Shabaana A Khader, Michael Angelo, Deepak Kaushal, Smriti Mehra

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Erin F McCaffreyDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.
Alea C DelmastroDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-7959-3165
Bindu SinghTexas Biomedical Research Institute, San Antonio, TX, USA.
Annu DeviTexas Biomedical Research Institute, San Antonio, TX, USA.
Nadia A GoldenTulane National Primate Research Center, LA, USA.
Shabaana A KhaderDepartment of Microbiology and Immunology, University of Chicago School of Medicine, Chicago, IL, USA.
Michael AngeloDepartment of Pathology, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-1531-5067
Deepak KaushalTexas Biomedical Research Institute, San Antonio, TX, USA.
Smriti MehraTexas Biomedical Research Institute, San Antonio, TX, USA.

Funding

Viral Testing CoreU42OD010442 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Deepak Kaushal · 2012 to 2026
$35.6M
MOLECULAR &CELLULAR IMMUNOBIOLOGYT32AI007290 · NIAID · STANFORD UNIVERSITY · PI Sean Curtis Bendall, Olivia M Martinez · 1985 to 2026
$27.0M
ROLE OF INDUCIBLE BRONCHUS ASSOCIATED LYMPHOID TISSUE IN LATENT TUBERCULOSISR01AI111914 · NIAID · WASHINGTON UNIVERSITY · PI KAUSHAL, DEEPAK, KHADER, SHABAANA A. · 2015 to 2025
$11.1M
Texas Developmental Center for AIDS ResearchP30AI161943 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI RICE, ANDREW P · 2021 to 2025
$8.3M
Interdisciplinary NexGen TB research Advancement Center (IN-TRAC)P30AI168439 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI JOANNE TURNER · 2022 to 2026
$6.9M
Myeloid and lymphoid immunity-specific mechanisms of IDO mediated immunosuppression and its reversal, during TBR01AI134245 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI Smriti Mehra · 2018 to 2026
$6.2M
Immune Correlates of Protection from TBR01AI134240 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI KAUSHAL, DEEPAK · 2017 to 2022
$4.8M
SigH based attenuated, efficacious Mtb vaccines to protect against lethal TBR01AI138587 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI JAGANNATH, CHINNASWAMY, KAUSHAL, DEEPAK · 2018 to 2022
$4.4M
Modulating Indoleamines to Optimize Immunity in the Setting of Mtb/HIV Co-infectionR01AI181701 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI Smriti Mehra · 2024 to 2026
$2.8M
Impact of HIV on the human alveolar environment drivingthe early events of Mycobacterium tuberculosis infectionR01AI184581 · NIAID · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI SCHLESINGER, LARRY S., TORRELLES, JORDI B · 2024 to 2025
$2.0M
Significant upgrade and expansion of the Southwest National Primate Research Center Pathology UnitS10OD028732 · OD · TEXAS BIOMEDICAL RESEARCH INSTITUTE · PI KAUSHAL, DEEPAK · 2020 to 2020
$489k
Role of IDO in tryptophan pathway during Mycobacterial Tuberculosis infectionR21AI128130 · NIAID · TULANE UNIVERSITY OF LOUISIANA · PI MEHRA, SMRITI · 2017 to 2018
$449k
NIAID NIH HHS P30 AI161943NIAID NIH HHS P30 AI168439NIAID NIH HHS R01 AI111914NIAID NIH HHS R01 AI134240NIAID NIH HHS R01 AI134245NIAID NIH HHS R01 AI138587NIAID NIH HHS R01 AI181701NIAID NIH HHS R01 AI184581NIAID NIH HHS R21 AI128130NIAID NIH HHS T32 AI007290NIH HHS S10 OD028732NIH HHS U42 OD010442
6 · The paper itself

Abstract

Granulomas, the hallmark of tuberculosis (TB) disease, can both restrict

Indexed as

granulomamacaquemultiplexed imagingMycobacterium tuberculosis

Identifiers

PMID41473286
PMCPMC12747256

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.