ArticleThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale2025
Clinical Characteristics and Real-World Drug Treatment of Severe Pertussis in Children: A Retrospective Study.
Article in The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Clinical Characteristics and Real-World Drug Treatment of Severe Pertussis in Children: A Retrospective Study.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025Article
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Authors and funding
3 authors.
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Abstract
Background: Pertussis is an acute respiratory infectious disease caused by Methods: This study collected clinical data from 76 children with pertussis treated in our hospital from January 2024 to December 2024. The patients were divided into severe and nonsevere groups based on their condition. The clinical data, drug treatments, hospitalization costs, and hospital stays were compared between the two groups to evaluate the efficacy and economic impact of different treatments. Results: The study found that the highest incidence of pertussis occurred in infants aged 6 weeks to 3 months. Severe pertussis cases had significantly longer hospitalization times, treatment durations, and antibiotic therapy courses than the nonsevere group. Macrolide antibiotics remain the first-line treatment, but resistance to these drugs has emerged in certain regions, making sulfamethoxazole-trimethoprim (SMZ-TMP) an effective alternative. Steroid treatment was effective in symptom relief but did not affect cure rates or recurrence. Conclusion: This study shows that pertussis remains common in infants, with severe cases presenting greater treatment challenges. For children with macrolide-resistant pertussis, SMZ-TMP shows good efficacy. Proper selection of antibiotics and symptomatic treatment are essential for improving patient outcomes and reducing complications.
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