Evidence map›Paper›PMID 41473183›Full record

ArticleFrontiers in nutrition2025

Nutritional factors and survival in a cohort of patients with myelofibrosis.

Silvio Buscemi, Piero Colombrita, Marco Santoro, Cristiana Randazzo, Carola Buscemi, Anna Maria Barile, Roberta Caruso, Martina Lombardo, Salvatrice Mancuso, Orazio Gambino and 2 more

Abstract read
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In one paragraph

Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Silvio BuscemiDepartment of Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, Palermo, Italy.
Piero ColombritaDepartment of Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, Palermo, Italy.
Marco SantoroHematology Unit, University Hospital Policlinico "P. Giaccone", Palermo, Italy.
Cristiana RandazzoDepartment of Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, Palermo, Italy.
Carola BuscemiDepartment of Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, Palermo, Italy.
Anna Maria BarileDepartment of Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, Palermo, Italy.
Roberta CarusoDepartment of Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, Palermo, Italy.
Martina LombardoDepartment of Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, Palermo, Italy.
Salvatrice MancusoDepartment of Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, Palermo, Italy.
Orazio GambinoDepartment of Engineering, University of Palermo, Palermo, Italy.
Giuseppe BazanDepartment of Biological, Chemical and Pharmaceutical Sciences and Technologies (STEBICEF), University of Palermo, Palermo, Italy.
Sergio SiragusaDepartment of Promozione della Salute, Materno-Infantile, Medicina Interna e Specialistica di Eccellenza (PROMISE), University of Palermo, Palermo, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Myelofibrosis (MF) is classified among the chronic myeloproliferative neoplasms and presents unique nutritional challenges. Inflammation can trigger metabolic changes that lead to malnutrition and, ultimately, cachexia. Splenomegaly, which may occupy much of the abdomen and compress the stomach, can cause early satiety and further contribute to malnutrition. We investigated associations between nutritional parameters, clinical features, and survival in individuals with MF. Methods: Forty-five individuals with MF (21 males, 24 females) were included and compared with a healthy control group of 351 individuals (157 males, 194 females). Body composition (bioelectrical impedance analysis), resting metabolic rate (RMR), and substrate oxidation (indirect calorimetry) were assessed. Results: The mean follow-up was 31 ± 8 months, during which seven deaths occurred. MF was associated with malnutrition; patients exhibited lower bioelectrical phase angle values and higher RMR (32.4 ± 4.2 vs. 28.5 ± 3.6 kcal/kg-fat-free mass/24 h; Discussion: Nutritional factors may serve as important predictors of survival in individuals with MF and should be considered in future supportive interventions aimed at improving both survival and quality of life.

Indexed as

energy expendituremalnutritionmyelofibrosisphase anglesplenomegalysurvival

Identifiers

PMID41473183
PMCPMC12746659

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