Evidence map›Paper›PMID 41473181›Full record

ArticleCanadian respiratory journal2025

Gastroesophageal Reflux, Sleep-Disordered Breathing, and Outcomes in Patients With Idiopathic Pulmonary Fibrosis.

Braden Ellis, Daniel Morris, Andrea Peterson, Isabella Marquetti, Luke Manietta, Mikal Borg, Stephen Halliday, Amy Malik, Nathan Sandbo, Ronald Gangnon and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian respiratory journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Braden EllisDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA, uwm.edu.ORCID 0009-0000-3582-3961
Daniel MorrisDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA, uwm.edu.ORCID 0009-0005-4579-817X
Andrea PetersonDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA, uwm.edu.ORCID 0009-0006-0765-9547
Isabella MarquettiDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA, uwm.edu.ORCID 0009-0001-8328-5579
Luke ManiettaDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA, uwm.edu.ORCID 0009-0003-9887-395X
Mikal BorgDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA, uwm.edu.ORCID 0009-0004-1870-3262
Stephen HallidayDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA, uwm.edu.ORCID 0000-0002-4944-3748
Amy MalikDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA, uwm.edu.ORCID 0009-0001-4220-8358
Nathan SandboDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA, uwm.edu.ORCID 0000-0002-5732-4589
Ronald GangnonDepartment of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA, uwm.edu.ORCID 0000-0003-2587-6714
Christopher J FrancoisDepartment of Radiology, Mayo Clinic, Rochester, Minnesota, USA, mayo.edu.ORCID 0000-0001-5254-1181
Mihaela TeodorescuDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA, uwm.edu.ORCID 0000-0002-4490-6926

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Gastroesophageal reflux disease (GERD) and obstructive sleep apnea (OSA) may negatively impact idiopathic pulmonary fibrosis (IPF), but data on their concurrent contributions are lacking. We aimed to test the contributions of GERD and sleep-disordered breathing (SDB) to IPF outcomes. Methods: We performed a cross-sectional, exploratory study on subjects with IPF. Clinically established GERD diagnosis, questionnaires (Nocturnal GERD Symptom Severity and Impact Questionnaire [N-GSSIQ], the NIH Patient-Reported Outcomes Measurement Information System [PROMIS] sleep impairment and fatigue scales, and Short Form-36 [SF-36]), full pulmonary function tests (PFT), six-minute walk test (6MWT), and nocturnal polysomnography (PSG) were obtained. Results: Among Conclusions: A nocturnal burden of GERD was detected and related to sleep disruption, including PLMs, and to daytime complaints. SDB/OSA, of a severity known to have significant health consequences, was common; it was adversely related to pulmonary diffusion and exercise capacity. These findings call for comprehensive, early evaluation of GERD and OSA for improved IPF outcomes.

Indexed as

Gastroesophageal RefluxIdiopathic Pulmonary FibrosisSleep Apnea, ObstructiveSleep Apnea SyndromesAgedCross-Sectional StudiesFatigueFemaleHumansMaleMiddle AgedPatient Reported Outcome MeasuresPolysomnographyQuality of LifeRespiratory Function TestsSurveys and Questionnairesgastroesophageal refluxidiopathicobstructivepatient-centered outcomesperiodic limb movementpulmonary fibrosissleep apneasleep-disordered breathing

Identifiers

PMID41473181
PMCPMC12745840

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.