Evidence map›Paper›PMID 41473107›Full record

ArticleFrontiers in veterinary science2025

Case Report: Steroid-responsive immune-mediated thyroiditis in a young dog with multi-systemic pyogranulomatous inflammation.

Kyle L Granger, Claire D Tucker, Amanda Garrick, Paula Yoon, Christopher Olmo, A R Moore, Paula A Schaffer, Sarah Shropshire, Kelly E Hall

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in veterinary science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kyle L GrangerDepartment of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.
Claire D TuckerDepartment of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.
Amanda GarrickDepartment of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.
Paula YoonDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, United States.
Christopher OlmoDepartment of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, United States.
A R MooreDepartment of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Science, Colorado State University, Fort Collins, CO, United States.
Paula A SchafferDepartment of Microbiology, Immunology, and Pathology, College of Veterinary Medicine and Biomedical Science, Colorado State University, Fort Collins, CO, United States.
Sarah ShropshireDepartment of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.
Kelly E HallDepartment of Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, CO, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 3-year-old neutered male Posavac Hound presented with rapidly progressive cervical swelling, respiratory distress, and systemic inflammation. Diagnostics confirmed severe hypothyroidism [total thyroxine (TT4) < 0.5 μg/dL, thyroid-stimulating hormone (TSH) 5.54 ng/dL], elevated thyroglobulin autoantibodies (TgAA 131%), hyperglobulinemia, hypoalbuminemia, and mild ionized hypercalcemia. Imaging showed bilateral thyroid enlargement with cavitated necrosis, pulmonary nodules, and lymphadenopathy. Cytology revealed pyogranulomatous inflammation without infectious organisms, and infectious disease screening was negative. Protein electrophoresis and immunofixation revealed elevated IgG4, suggesting immune-mediated dysregulation. The dog responded rapidly to prednisolone and thyroid hormone supplementation, with resolution of clinical signs and normalization of inflammatory markers by ~60 days. This report describes a unique case of immune-mediated thyroiditis with systemic inflammatory involvement that responded to steroids, emphasizing the importance of considering immune-mediated thyroiditis as a differential diagnosis for acute cervical neck swelling in a young dog with concurrent pulmonary involvement.

Indexed as

canine hypothyroidismdogimmune-mediated diseasesteroid-responsive diseasethyroiditis

Identifiers

PMID41473107
PMCPMC12745206

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.