ArticleJTCVS open2025
The role of diagnostic laparoscopy in staging distal esophageal adenocarcinoma.
Article in JTCVS open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
15 authors.
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Abstract
Objectives: The study objectives were to determine whether diagnostic laparoscopy improves staging accuracy in selected patients with distal esophageal adenocarcinoma and to identify clinicopathologic features associated with positive diagnostic laparoscopy. Methods: Patients with distal esophageal adenocarcinoma who underwent diagnostic laparoscopy from 2000 to 2023 at a single institution were identified from a prospectively maintained surgical database. Exclusion criteria included performance of diagnostic laparoscopy after systemic therapy, absence of staging positron computed tomography/computed tomography, and M1 disease before diagnostic laparoscopy. Fisher exact test and Wilcoxon rank-sum test were used to compare categorical and continuous variables, respectively, between patients with negative and positive diagnostic laparoscopy. Clinicopathologic features were assessed using multivariable logistic regression. Results: In total, 226 of 2131 patients with distal esophageal adenocarcinoma (11%) underwent diagnostic laparoscopy; 93% of these patients (211/226) had clinical T stage 3 or more. Most patients had clinical stage III disease before diagnostic laparoscopy (205/226 [91%]). In total, 183 patients (81%) had negative diagnostic laparoscopy, and 43 patients (19%) had positive diagnostic laparoscopy. In 40 patients (20%), disease was upstaged from III to IVB after positive diagnostic laparoscopy. Distal esophageal adenocarcinoma with signet ring feature (odds ratio, 2.45, 95% CI, 1.05-5.86; Conclusions: Signet ring feature is associated with peritoneal disease. The use of diagnostic laparoscopy in these patients may lead to better staging and more appropriate treatment strategies.
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