Evidence map›Paper›PMID 41473050›Full record

ArticleJTCVS open2025

Propensity-matched analysis of the impact of saphenous vein graft external stenting on clinical outcomes in coronary bypass surgery: The RESTART study.

Luca P Weltert, Eric A Secemsky, Gil Bolotin, Tom Friedman, Paolo Centofanti, Viviana Sebastiano, Samuel Fusca, Sigrid E Sandner, Marija Pljakova, Stefanos Demertzis and 7 more

Abstract read
In one paragraph

Article in JTCVS open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Luca P WeltertDepartment of Cardiac Surgery, European Hospital, Rome, Italy.
Eric A SecemskyDepartment of Medicine, Harvard Medical School, Boston, Mass.
Gil BolotinDepartment of Cardiac Surgery, Rambam Health Care Campus, Haifa, Israel.
Tom FriedmanDepartment of Cardiac Surgery, Rambam Health Care Campus, Haifa, Israel.
Paolo CentofantiCardiac Surgery Division, Mauriziano Hospital, Turin, Italy.
Viviana SebastianoCardiac Surgery Division, Mauriziano Hospital, Turin, Italy.
Samuel FuscaDepartment of Cardiac Surgery, European Hospital, Rome, Italy.
Sigrid E SandnerDepartment of Cardiac Surgery, Medical University Vienna, Vienna, Austria.
Marija PljakovaDepartment of Cardiac Surgery, Medical University Vienna, Vienna, Austria.
Stefanos DemertzisCardiac Surgery, Cardiocentro Ticino, Lugano, Switzerland.
Tiziano TorreCardiac Surgery, Cardiocentro Ticino, Lugano, Switzerland.
John T DonovanHeart & Thoracic Surgery, Herzzentrum Trier, Krankenhaus der Barmherzigen Bruder, Trier, Germany.
Ivar FriedrichCardiac Surgery, CardioClinic Köln, Köln, Germany.
Siling LiSmith Center for Outcomes Research, Beth Israel Deaconess Medical Center (BIDMC), Boston, Mass.
Marcus FlatherCardiovascular & Metabolic Health, University of East Anglia, and Norwich University Hospital, Norwirch, United Kingdom.
Stephen GerryCentre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology & Musculoskeletal Sciences, University of Oxford, Oxford, United Kingdom.
David P TaggartNuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: External saphenous vein graft stenting has been shown to reduce intimal hyperplasia, lumen irregularities, and flow disturbances after coronary artery bypass grafting (CABG). The objective of this study is to evaluate the effect of saphenous vein graft external stenting on clinical outcomes up to 5 years. Methods: Outcomes for patients who received external vein graft stenting in an international, real-world cohort were compared in a propensity matched analysis with patients from the Arterial Revascularization Trial (ISRCTN46552265). All eligible patients required an internal mammary artery graft to the left anterior descending coronary artery, received at least one vein graft, and survived to discharge. The primary end point was major adverse cardiovascular and cerebrovascular events at 1 year after surgery, consisting of all-cause mortality, myocardial infarction, repeat revascularization, and cerebrovascular accident. Secondary end points included 5-year major adverse cardiovascular and cerebrovascular events with and without stroke and annualized target vessel revascularization. Results: In total, 789 treated and 2205 control patients were included. At 1 year after CABG, the weighted hazard ratio comparing outcomes between treated and control patients was 0.60 (90% confidence interval, 0.38-0.94, Conclusions: The current study demonstrates that external vein graft stenting is associated with a significantly lower risk of experiencing adverse clinical outcomes up to 5 years after surgery compared with standard of care.

Indexed as

cardiac surgeryclinical outcomescoronary artery bypass grafting (CABG)coronary artery diseasecoronary heart disease in adultsMACCEvein graft external support device

Identifiers

PMID41473050
PMCPMC12745130

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.