ArticleACS applied electronic materials2025
Development of a Piezoelectric Immunosensor to Rapidly Measure Prohibitin‑1 as a Prognostic Biomarker for Sepsis and Other Serious Infectious Diseases.
Article in ACS applied electronic materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Sepsis is a life-threatening condition and the leading cause of mortality worldwide, particularly when an affected patient develops multiple organ dysfunction syndrome (MODS), a serious complication defined as progressive and potentially irreversible dysfunction in two or more organ systems. Clinical and experimental studies strongly suggest that patient outcomes with sepsis would improve if the risk for MODS and mortality could be identified in the first few hours after the onset of symptoms. We present an approach leveraging quartz crystal microbalance with dissipation monitoring (QCM-D) technology for rapid (∼30 min) detection of prohibitin-1 (PHB1), a protein with pleiotropic biological function that dramatically increases in blood during the acute phase of an infection. The feasibility of detection and reproducible quantification of recombinant PHB1 in physiological buffered conditions is described. Sensitivity and detection limit for the third overtone (12.19 Hz μg
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