ArticleNigerian medical journal : journal of the Nigeria Medical Association
Efficacy and Safety of Steroids in Acute Heart Failure: A Systematic Review and Meta-analysis.
Article in Nigerian medical journal : journal of the Nigeria Medical Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Persistent congestion in acute heart failure (AHF) is associated with worse clinical outcomes. The use of steroids may provide therapeutic benefits by alleviating congestion, overcoming diuretic resistance, and mitigating the harmful effects of neurohormonal activation. This approach could potentially improve hemodynamic status and support better management of AHF, ultimately leading to enhanced patient recovery and reduced complications. Objective: To evaluate the efficacy and safety of steroids in acute heart failure (AHF) as compared to the standard of care (SOC). Search strategy: We used PubMed, Scopus, Google Scholar, and a manual search to identify Randomized controlled trials published up to October 15, 2024.The protocol was registered in PROSPERO (CRD42024601261). Selection Criteria: All full-text randomized control trials (RCTs) that investigated steroids in heart failure were included. Results were pooled, where appropriate, using a random-effects model. Results: Three RCTs with 563 participants [282 Steroid, 281 (SOC)] were identified. No statistically significant difference is seen in mortality as well as NT-proBNP levels between the steroid plus SOC and control group (RR=0.59, 95% CI=0.06-6.13, p=0.66, (I⊃2;=51%, p=0.15) and (MD=0.14, 95% CI=-0.62 to 0.90, p=0.71, I⊃2;=91%, p<0.0006), respectively. Conclusion: Steroids have no significant effect on all-cause mortality or NT-proBNP levels in patients with AHF.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.