Evidence map›Paper›PMID 41472906›Full record

ArticleIJU case reports2026

Fatal Tumor Lysis Syndrome Induced by Pembrolizumab in Advanced Renal Pelvis Cancer.

Takashi Asakura, Toshiaki Shinojima, Shinnosuke Hiruta, Hirotaka Asakura

Abstract read
In one paragraph

Article in IJU case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Takashi AsakuraDepartment of Urology Saitama Medical University Saitama Japan.ORCID https://orcid.org/0009-0006-7014-1783
Toshiaki ShinojimaDepartment of Urology Saitama Medical University Saitama Japan.ORCID https://orcid.org/0000-0001-5005-5366
Shinnosuke HirutaDepartment of Urology Saitama Medical University Saitama Japan.
Hirotaka AsakuraDepartment of Urology Saitama Medical University Saitama Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Tumor lysis syndrome (TLS) arises from the rapid breakdown of tumor cells during oncological treatment. Although TLS is rarely observed in solid tumors, few studies have documented instances of TLS associated with pembrolizumab. This report presents a case involving pembrolizumab-induced TLS. Case Presentation: A 76-year-old male patient with advanced renal pelvis cancer (T3N2M1) was treated with pembrolizumab as second-line therapy. Four days after the initiation of therapy, the patient developed TLS. Despite intensive therapeutic interventions, he succumbed to the condition on the 10th day. Conclusion: This case highlights a fatal TLS episode after pembrolizumab. Given its poor prognosis, blood monitoring and prophylaxis are warranted in intermediate-risk patients, particularly when multiple non-renal risk factors are present.

Indexed as

pembrolizumabrenal pelvis cancertumor lysis syndrome

Identifiers

PMID41472906
PMCPMC12747779

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.