Evidence map›Paper›PMID 41472893›Full record

ArticleJournal of the Endocrine Society2026

Time-dependent Increase in Cortisol after 1-mg Overnight Dexamethasone Suppression Test in Adrenal Incidentalomas.

Seong Hee Ahn, Kyong Yeun Jung, Chang Ho Ahn, Seung Shin Park, You-Bin Lee, A Ram Hong, Eu Jeong Ku, Hyo-Jeong Kim, Seongbin Hong, Jung-Min Koh and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Seong Hee AhnDivision of Endocrinology and Metabolism, Department of Internal Medicine, Inha University Hospital, Inha University College of Medicine, 22212 Incheon, Korea.
Kyong Yeun JungDivision of Endocrinology and Metabolism, Department of Internal Medicine, Nowon Eulji University Hospital, Eulji University School of Medicine, 01830 Seoul, Korea.
Chang Ho AhnDepartment of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 13620 Seongnam, Korea.
Seung Shin ParkDepartment of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, 03080 Seoul, Korea.
You-Bin LeeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 06351 Seoul, Korea.
A Ram HongDivision of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Hwasun Hospital, Chonnam University Medical School, 58128 Gwangju, Korea.
Eu Jeong KuDivision of Endocrinology and Metabolism, Department of Internal Medicine, Seoul National University Hospital Healthcare System Gangnam Center, Seoul National University College of Medicine, 06236 Seoul, Korea.
Hyo-Jeong KimDivision of Endocrinology and Metabolism, Department of Internal Medicine, Nowon Eulji University Hospital, Eulji University School of Medicine, 01830 Seoul, Korea.
Seongbin HongDivision of Endocrinology and Metabolism, Department of Internal Medicine, Inha University Hospital, Inha University College of Medicine, 22212 Incheon, Korea.
Jung-Min KohDivision of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 05505 Seoul, Korea.
Jung Hee KimDepartment of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, 03080 Seoul, Korea.ORCID https://orcid.org/0000-0003-1932-0234
Seung Hun LeeDivision of Endocrinology and Metabolism, Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, 05505 Seoul, Korea.ORCID https://orcid.org/0000-0003-0496-247X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Guidelines recommend the 1-mg overnight dexamethasone suppression test (ODST) for diagnosing mild autonomous cortisol secretion (MACS) in adrenal incidentalomas (AI). Age may influence cortisol levels after 1-mg ODST (post-ODST cortisol levels). This study investigated changes in post-ODST cortisol levels over time in Korean patients with AI. Methods: This retrospective, multicenter cohort study included 1063 patients with AI from 4 tertiary hospitals between 2003 and 2022. Post-ODST cortisol changes were evaluated using the ODST ratio (last to baseline measurement). A generalized additive model assessed the association between age and post-ODST cortisol levels. Multivariable logistic regression estimated odds ratios (OR) for post-ODST cortisol progression by follow-up duration. Results: The ODST ratio increased with follow-up duration (β = .063, Conclusion: Cortisol levels after 1-mg ODST increased over time, suggesting an age-related effect and highlighting the need for age-tailored diagnostic and management strategies for MACS in older patients with AI.

Indexed as

adrenal incidentalomacortisolmild autonomous cortisol secretionovernight dexamethasone suppression test

Identifiers

PMID41472893
PMCPMC12745602

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.