ArticleFrontiers in cardiovascular medicine2025
Initial high-dose
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Background: Methods: A retrospective observational study included 307 hypertensive patients with HFrEF who initiated BB therapy and were admitted to the cardiology department at West China Hospital, Sichuan University. Patients' demographic and clinical information was collected through the electronic medical record (EMR) system. Patients were categorized into a high-dose group if their initial BB dose exceeded 1/8 of the target dose, all other patients were assigned to the standard-dose group. Multivariate logistic forward regression analysis was performed to explore factors influencing the prescriptions of intial high-dose BB and adverse safety outcomes related to BB therapy during hospitalization, including bradycardia, hypotension, acute HF, wheezing requiring bronchodilator therapy, and BB dose reduction or cessation. Results: Seventy patients (22.8%) were initially prescribed high-dose BB. Logistic forward regression analysis revealed that only coronary heart disease was negatively associated with the prescriptions of initial high-dose BB, with an odds ratio of 0.435 (95% CI: 0.247-0.763, Conclusion: Prescriptions of initial high-dose BB in hypertensive patients with HFrEF were not associated with an increased incidence of adverse safety outcomes. These findings indicate that initial high-dose BB therapy could be a viable strategy for this population.
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