ArticleFrontiers in cardiovascular medicine2025
The Shenlian Fumai Granule attenuates Ach-CaCl
Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
Background: Preliminary clinical studies indicate that Shenlian Fumai Granule (SLFM) reduces the incidence of arrhythmias following radiofrequency ablation in patients with atrial fibrillation (AF) and improves clinical symptoms. This study investigates the preventive effects and underlying mechanisms of SLFM on AF, providing robust evidence to support its clinical application. Methods: The potential therapeutic effects of SLFM on AF were investigated using network pharmacology. Subsequently, High Performance Liquid Chromatography-Mass Spectrometry (HPLC-MS) was employed for further analysis of SLFM, while molecular docking was utilized to validate potential targets. The impact of SLFM on the electrophysiology of rat hearts was examined during Langendorff perfusion through electrical mapping. AF in rats was induced using Ach (66 μg/mL) and CaCl Results: A total of 107 active compounds were extracted, and their relationships with Traditional Chinese Medicines (TCMs) and protein targets were analyzed. The intersection of potential TCM target genes and genes related to AF identified four significant genes. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses indicated that these targets may be involved in various pathways associated with AF. Furthermore, SLFM was found to prolong the atrial effective refractory period in a concentration-dependent manner, suggesting a potential anti-atrial arrhythmia effect. In a rat model of AF induced by Ach-CaCl Conclusion: This study demonstrated that SLFM plays a critical role in suppressing atrial electrical and structural remodeling induced by Ach-CaCl
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