Evidence map›Paper›PMID 41472856›Full record

ArticleiMeta2025

Nationwide profiling of vaginal microbiota in Chinese women reveals age-dependent shifts and predictive biomarkers for reproductive health.

Cancan Qi, Yingxuan Zhang, Wei Qing, Rongdan Chen, Zuyi Zhou, Yumei Liu, Enzhong Chen, Wenyi Chen, CALM2004 Consortium Investigators, Hongwei Zhou and 1 more

Abstract readLetter
In one paragraph

Article in iMeta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Cancan QiMicrobiome Medicine Center, Department of Laboratory Medicine ZhuJiang Hospital, Southern Medical University Guangzhou China.
Yingxuan ZhangMicrobiome Medicine Center, Department of Laboratory Medicine ZhuJiang Hospital, Southern Medical University Guangzhou China.
Wei QingMicrobiome Medicine Center, Department of Laboratory Medicine ZhuJiang Hospital, Southern Medical University Guangzhou China.
Rongdan ChenMicrobiome Medicine Center, Department of Laboratory Medicine ZhuJiang Hospital, Southern Medical University Guangzhou China.
Zuyi ZhouMicrobiome Medicine Center, Department of Laboratory Medicine ZhuJiang Hospital, Southern Medical University Guangzhou China.
Yumei LiuMicrobiome Medicine Center, Department of Laboratory Medicine ZhuJiang Hospital, Southern Medical University Guangzhou China.
Enzhong ChenMicrobiome Medicine Center, Department of Laboratory Medicine ZhuJiang Hospital, Southern Medical University Guangzhou China.
Wenyi ChenMicrobiome Medicine Center, Department of Laboratory Medicine ZhuJiang Hospital, Southern Medical University Guangzhou China.
CALM2004 Consortium Investigators
Hongwei ZhouMicrobiome Medicine Center, Department of Laboratory Medicine ZhuJiang Hospital, Southern Medical University Guangzhou China.
Muxuan ChenMicrobiome Medicine Center, Department of Laboratory Medicine ZhuJiang Hospital, Southern Medical University Guangzhou China.ORCID https://orcid.org/0000-0002-8961-2649

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The vaginal microbiome is central to reproductive health, yet large-scale studies in East Asian populations remain scarce. Here, we characterized the vaginal microbiota of 6423 Chinese women of reproductive age across 18 provinces and assessed associations with 33 host factors. We observed a striking compositional transition around age 40, marked by declining

Identifiers

PMID41472856
PMCPMC12747552

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.