Evidence map›Paper›PMID 41472851›Full record

ArticleiMeta2025

Genome-wide CRISPR screen reveals an uncharacterized spliceosome regulator as new candidate immunotherapy target.

Tong Shao, Chuanyang Liu, Jingyu Kuang, Sisi Xie, Ying Qu, Yingying Li, Lulu Zhang, Fangzhou Liu, Yanhua Qi, Tao Hou and 15 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iMeta, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Tong ShaoCollege of Science National University of Defense Technology Changsha China.
Chuanyang LiuCollege of Science National University of Defense Technology Changsha China.
Jingyu KuangCollege of Science National University of Defense Technology Changsha China.
Sisi XieCollege of Science National University of Defense Technology Changsha China.
Ying QuCollege of Science National University of Defense Technology Changsha China.
Yingying LiCollege of Science National University of Defense Technology Changsha China.
Lulu ZhangKey Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science Chinese Academy of Sciences Shanghai China.
Fangzhou LiuCollege of Life Science Zhejiang University Hangzhou China.
Yanhua QiCollege of Science National University of Defense Technology Changsha China.
Tao HouDepartment of Oncology, The Second Xiangya Hospital Central South University Changsha China.
Ming LiCollege of Science National University of Defense Technology Changsha China.
Sujuan ZhangDepartment of Oncology, The Second Xiangya Hospital Central South University Changsha China.
Yu LiuCollege of Science National University of Defense Technology Changsha China.
Zhixiang YuanCollege of Science National University of Defense Technology Changsha China.
Jiali LiuCollege of Science National University of Defense Technology Changsha China.
Yanming HuDepartment of Oncology, The Second Xiangya Hospital Central South University Changsha China.
Jingyang WangCollege of Science National University of Defense Technology Changsha China.
Chenghu SongDepartment of Cardiothoracic Surgery, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center Nanjing Medical University Wuxi China.
Shaowei ZhangCollege of Science National University of Defense Technology Changsha China.
Lingyun ZhuCollege of Science National University of Defense Technology Changsha China.
Jianzhong ShaoCollege of Life Science Zhejiang University Hangzhou China.
Aifu LinCollege of Life Science Zhejiang University Hangzhou China.
Wenjun MaoDepartment of Cardiothoracic Surgery, the Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi People's Hospital, Wuxi Medical Center Nanjing Medical University Wuxi China.
Guangchuan WangKey Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science Chinese Academy of Sciences Shanghai China.
Lvyun ZhuCollege of Science National University of Defense Technology Changsha China.ORCID https://orcid.org/0000-0003-2288-5981

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer immune evasion is orchestrated by tumor-intrinsic molecular constraints that remain incompletely defined. Here, we performed an in vivo genome-wide clustered regularly interspaced short palindromic repeats (CRISPR) loss-of-function screen to catalogue gene regulatory determinants of immune evasion in cancer cells. We identify

Indexed as

antitumor immunityC9ORF50CRISPR screenintrinsically disordered proteinliquid–liquid phase separationRNA splicingtherapeutic targets

Identifiers

PMID41472851
PMCPMC12747536

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.