ArticleFrontiers in pharmacology2025
Opioid-free anesthesia with esketamine combined with interpectoral plane block and pectoralis-serratus plane blocks in radical mastectomy: a randomized controlled trial.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Effects of opioid-free anesthesia on postoperative anxiety in patients undergoing modified radical mastectomy for breast cancer: a randomized controlled trial.BMC anesthesiology · 2026Trial
- Anesthesia-Informed Approaches to Insomnia: Shared Neural Circuits, Biomimetic Sleep, and Emerging Interventional Strategies.Nature and science of sleep · 2026Review
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Authors and funding
9 authors.
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Abstract
Objective: Opioid-free anesthesia (OFA) is an emerging technique that aims to reduce or eliminate intraoperative opioid use. Previous studies have shown that OFA is associated with reduced postoperative opioid consumption and fewer adverse events. This study investigated the impact of OFA on the quality of recovery (QoR) in patients undergoing radical mastectomy for breast cancer. Methods: We enrolled 130 patients scheduled for radical mastectomy and randomly assigned them to either the opioid-free anesthesia (OFA) group or the opioid-based anesthesia (OA) group. Data from 124 patients were ultimately analyzed. The primary outcome was the Quality of Recovery-40 (QoR-40) score at 24 and 48 h postoperatively. Secondary outcomes included the Numerical Rating Scale (NRS) pain scores at 30 min, 24 h, and 48 h postoperatively, perioperative hemodynamic parameters, post-anesthesia care unit (PACU) stay duration, and the incidence of related adverse events. Results: Postoperative QoR-40 scores were significantly higher in the OFA group than in the OA group at both 24 h (176.1 ± 3.7 vs 169.7 ± 3.3; mean difference 6.4, 95% CI 5.2-7.7, Conclusion: For patients undergoing radical mastectomy, opioid-free anesthesia (OFA) utilizing esketamine combined with Interpectoral Plane (IPP) and Pectoralis-Serratus Plane (PSP) blocks significantly improved postoperative recovery quality compared to conventional opioid-based anesthesia (OA).
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