Global seroprevalence and distribution of Getah virus in domestic and wild animals: A systematic review and meta-analysis.

Background and Aim: Getah virus (GETV), a mosquito-borne alphavirus of veterinary importance, has caused periodic outbreaks in domestic animals, especially in Asia. Although several studies have reported evidence of infection in animals, the overall global seroprevalence remains unclear. This study aimed to comprehensively synthesize available evidence on the worldwide seroprevalence of GETV in domestic and wild animals and identify epidemiological patterns across host types, regions, and detection methods. Materials and Methods: A systematic search of PubMed, Scopus, ScienceDirect, and Web of Science was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020 guidelines, without temporal or regional restrictions. Eligible studies reporting serological detection of GETV antibodies in animal populations were included. Data were extracted and analyzed using a DerSimonian-Laird random-effects model, with subgroup analyses stratified by country, host category, sampling period, and diagnostic method. Heterogeneity was quantified using I Results: Fifteen studies (n = 10,211 animals) met the inclusion criteria. The pooled global seroprevalence of GETV was 33.3% (95% confidence interval: 24.2-43.9; I Conclusion: This meta-analysis demonstrates that GETV is endemic among Asian animal populations, particularly domestic livestock, indicating substantial virus circulation across species. The findings underscore the need for enhanced veterinary surveillance, standardized serological testing, and One Health-oriented monitoring frameworks to detect and mitigate GETV transmission risks. The absence of data from Africa, Europe, and the Americas highlights an urgent need for geographically expanded research to better understand the virus's global distribution and zoonotic potential.