ArticleVeterinary world2025
Optimization of insulin-like growth factor-1 supplementation enhances oocyte quality by modulating oxidative stress and apoptotic pathways during
Article in Veterinary world, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Insulin-like growth factor 1 supplementation duringVeterinary world · 2026Article
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9 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background and Aim: Insulin-like growth factor-1 (IGF-1) plays a crucial role in folliculogenesis and oocyte maturation by regulating oxidative stress and apoptotic pathways. However, the optimal IGF-1 concentration for small ruminant oocytes, particularly the native Kacang goat, remains undefined. This study aimed to determine the optimal IGF-1 dose for improving oocyte quality during Materials and Methods: Ovaries (n = 120) were collected from local slaughterhouses, and cumulus-oocyte complexes were aspirated, selected, and randomly divided into four groups: Control (0 ng/mL IGF-1) and treatments with 50, 100, and 150 ng/mL IGF-1 supplementation. Mature oocytes were analyzed for oxidative stress biomarkers, including superoxide dismutase (SOD-1), glutathione (GSH), and malondialdehyde (MDA), using an enzyme-linked immunosorbent assay, and for apoptosis regulators, B-cell lymphoma 2-associated X protein (BAX), B-cell lymphoma-2 (BCL-2), and cytochrome c, using immunocytochemistry. Data were analyzed using one-way analysis of variance and Duncan's Results: IGF-1 supplementation produced concentration-dependent effects. The 100 ng/mL group (T2) exhibited the highest SOD-1 (2.07 ± 0.60) and GSH (8.07 ± 1.79) levels (p < 0.05), while MDA increased with higher IGF-1 doses, indicating a threshold beyond which oxidative stress is induced. Anti-apoptotic BCL-2 and cytochrome c expressions peaked at 50 ng/mL IGF-1 (10.73 ± 1.56 and 11.73 ± 0.99, respectively), whereas the pro-apoptotic marker BAX was lowest in the same group and increased at higher doses. The findings suggest that 50 ng/mL IGF-1 effectively maintains redox balance and mitochondrial stability through phosphatidylinositol 3-kinase/protein kinase B-mediated regulation. Conclusion: This study demonstrates, for the 1
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