Evidence map›Paper›PMID 41472747›Full record

ArticleFrontiers in immunology2025

CGRP restrains CD4

Xiaoshi Li, Ying Zhang, Wenlong Chen, Qingren Meng, Ai Huang, Jiayi Pan, Duan Chen, Yue Xiao, Jialin Wei, Heng Sun and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiaoshi LiDepartment of Biochemistry, SUSTech Homeostatic Medicine Institute, University Laboratory of Metabolism and Health of Guangdong, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Ying ZhangDepartment of Biochemistry, SUSTech Homeostatic Medicine Institute, University Laboratory of Metabolism and Health of Guangdong, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Wenlong ChenDepartment of Biochemistry, SUSTech Homeostatic Medicine Institute, University Laboratory of Metabolism and Health of Guangdong, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Qingren MengDepartment of Biochemistry, SUSTech Homeostatic Medicine Institute, University Laboratory of Metabolism and Health of Guangdong, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Ai HuangDepartment of Biochemistry, SUSTech Homeostatic Medicine Institute, University Laboratory of Metabolism and Health of Guangdong, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Jiayi PanDepartment of Biochemistry, SUSTech Homeostatic Medicine Institute, University Laboratory of Metabolism and Health of Guangdong, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Duan ChenDepartment of Biochemistry, SUSTech Homeostatic Medicine Institute, University Laboratory of Metabolism and Health of Guangdong, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Yue XiaoDepartment of Biochemistry, SUSTech Homeostatic Medicine Institute, University Laboratory of Metabolism and Health of Guangdong, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Jialin WeiDepartment of Biochemistry, SUSTech Homeostatic Medicine Institute, University Laboratory of Metabolism and Health of Guangdong, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Heng SunDepartment of Biochemistry, SUSTech Homeostatic Medicine Institute, University Laboratory of Metabolism and Health of Guangdong, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China.
Quan LiuDepartment of Biochemistry, SUSTech Homeostatic Medicine Institute, University Laboratory of Metabolism and Health of Guangdong, Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Calcitonin gene-related peptide (CGRP), a neuropeptide released by sensory neurons, plays an emerging role in immune regulation, yet its function in adaptive immunity remains poorly understood. Here, we identify the CGRP-RAMP1 pathway as a key intrinsic regulator of CD4 Methods: House dust mite (HDM) was used to induce allergic sensitization in mice. CGRP Results: CGRP Conclusions: These findings suggest a neuroimmune axis in which CGRP-RAMP1 pathway restrains allergic sensitization by directly modulating the immunobiology of CD4

Indexed as

Calcitonin Gene-Related PeptideCD4-Positive T-LymphocytesHypersensitivityReceptor Activity-Modifying Protein 1AnimalsDisease Models, AnimalLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutPyroglyphidaeSignal TransductionCalcitonin Gene-Related PeptideRamp1 protein, mouseReceptor Activity-Modifying Protein 1allergic sensitizationasthmaCD4+ T cellsCGRPneuroimmune

Identifiers

PMID41472747
PMCPMC12746649

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.