Evidence map›Paper›PMID 41472743›Full record

ArticleFrontiers in immunology2025

How conformational changes near the F pocket of MHC class I proteins mediate chaperone assisted peptide loading.

Simone Göppert, Sebastian Springer, Martin Zacharias

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Simone GöppertPhysics Department and Center of Protein Assemblies, Technical University of Munich, Garching, Germany.
Sebastian SpringerSchool of Science, Constructor University, Bremen, Germany.
Martin ZachariasPhysics Department and Center of Protein Assemblies, Technical University of Munich, Garching, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Efficient recognition of antigenic peptides bound to major histocompatibility complex (MHC) class I molecules on the surface of cells by immune cells requires sufficiently stable peptide-MHC I complexes. Antigenic peptides of 8-10 amino acids are typically bound in a narrow cleft between two flanking α Methods: The role of this α Results: The α Conclusions: The simulations indicate that the conformational shifts of the α

Indexed as

Histocompatibility Antigens Class IMolecular ChaperonesPeptidesAntigen PresentationHumansMembrane Transport ProteinsMolecular Dynamics SimulationProtein BindingProtein ConformationHistocompatibility Antigens Class IMembrane Transport ProteinsMolecular ChaperonesPeptidestapasinantigen presentationchaperone assisted bindingMHC class Ipeptide editingpeptide loadingtapasinTAPBPR

Identifiers

PMID41472743
PMCPMC12745280

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.