ReviewFrontiers in immunology2025
Acoustic immune reprogramming: a novel paradigm for spatiotemporally controlled immune regulation using ultrasound-responsive nanoplatforms.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The maintenance of immune homeostasis is a cornerstone of health, and mastering its regulation is now the focus of groundbreaking disease treatments. This review innovatively proposes and elucidates the "Acoustic Immune Reprogramming" framework: using ultrasound as a catalyst and nanoplatforms as carriers to enable hierarchical, spatiotemporally precise immune microenvironment interventions. It represents an advanced form of immunomodulation distinguished by its capacity for physical programming-the proactive and rational remodeling of cellular functions and tissue microecology with spatiotemporal precision and dose control unavailable to molecular agents alone. The review covers key technological advances in acoustic-mediated biological barrier penetration, local microenvironment programming, and precise delivery of drugs/genes/antibodies. It highlights functional remodeling of macrophages, neutrophils, dendritic cells (DCs), and the synergistic network effect. From a systems engineering perspective, acoustic nanoplatforms offer remote physical modulation, non-invasive activation, spatiotemporal control, and integrate bioinformatics, materials science, medical engineering, and AI. Three challenges are identified: (1) deciphering "black box" mechanisms via acoustic immune biology and single-cell multi-omics; (2) calibrating biological acoustic dosimetry for "physical input-to-immune effect" translation, plus personalized treatment prediction via cavitation standardization/digital twinning; (3) managing safety boundaries for "immune-programmable" nanomaterials and intelligent closed-loop systems. This review establishes the acoustic immune reprogramming framework, providing a theoretical basis for immune modulation/precision medicine and guiding interdisciplinary breakthroughs. Future advances may make acoustic "spatiotemporal immune sculpting" a cornerstone of intelligent medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.