Evidence map›Paper›PMID 41472717›Full record

ArticleJournal of tropical medicine2025

Stability and Perpetuation of Human T-Lymphotropic Virus 1 (HTLV-1) in Intrafamilial Transmissions of Infection in an Endemic Region of the Brazilian Amazon: A Pilot Study.

Cássia Cristine Costa Pereira, Milena Cristina Martins da Silva, Samir Mansour Moraes Casseb, Maria de Nazaré Lima Dos Reis, Louise de Souza Canto Covre, Edna Aoba Yassui Ishikawa, Leonardo Miranda Dos Santos, Carlos Araújo da Costa, Maisa Silva de Sousa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of tropical medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cássia Cristine Costa PereiraCellular and Molecular Biology Laboratory, Center for Tropical Medicine, Federal University of Para, Belem, Para, Brazil, ufpa.br.ORCID https://orcid.org/0000-0002-3175-1742
Milena Cristina Martins da SilvaCellular and Molecular Biology Laboratory, Center for Tropical Medicine, Federal University of Para, Belem, Para, Brazil, ufpa.br.ORCID https://orcid.org/0000-0002-5434-4242
Samir Mansour Moraes CassebCenter for Oncology Research, Federal University of Para, Belem, Para, Brazil, ufpa.br.ORCID https://orcid.org/0000-0002-7419-3381
Maria de Nazaré Lima Dos ReisCellular and Molecular Biology Laboratory, Center for Tropical Medicine, Federal University of Para, Belem, Para, Brazil, ufpa.br.ORCID https://orcid.org/0000-0002-1711-8633
Louise de Souza Canto CovreCellular and Molecular Biology Laboratory, Center for Tropical Medicine, Federal University of Para, Belem, Para, Brazil, ufpa.br.ORCID https://orcid.org/0000-0002-7510-6147
Edna Aoba Yassui IshikawaCellular and Molecular Biology Laboratory, Center for Tropical Medicine, Federal University of Para, Belem, Para, Brazil, ufpa.br.ORCID https://orcid.org/0000-0003-1017-3012
Leonardo Miranda Dos SantosCellular and Molecular Biology Laboratory, Center for Tropical Medicine, Federal University of Para, Belem, Para, Brazil, ufpa.br.ORCID https://orcid.org/0000-0003-0253-7277
Carlos Araújo da CostaCellular and Molecular Biology Laboratory, Center for Tropical Medicine, Federal University of Para, Belem, Para, Brazil, ufpa.br.
Maisa Silva de SousaCellular and Molecular Biology Laboratory, Center for Tropical Medicine, Federal University of Para, Belem, Para, Brazil, ufpa.br.ORCID https://orcid.org/0000-0001-9944-7838

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Human T-lymphotropic virus 1 (HTLV-1) is related to several clinical diseases, including adult T-cell leukemia/lymphoma and HTLV-1-associated myelopathy. Intrafamilial transmission of HTLV-1 is rarely reported in Brazil and worldwide. Objective: To identify HTLV-1 family transmissions in Belem, Para, the Amazon region of Brazil. Methods: Nested PCR of the pX gene, followed by restrict fragment length polymorphism (RFLP) to identify HTLV-1. Nested PCR of the 5'LTR region was used for nucleotide sequencing. Nucleotide sequences were analyzed using GENEIOUS 4.8.5 and MAFFT V.7. Results: The study investigated 72 individuals (14 index cases and 58 relatives) from 14 families, identifying HTLV-1 infection in 47% (27/58) of the relatives. Vertical transmission occurred in 14 (39%) of the 36 mother/child relationships investigated, and sexual transmission was observed in 14 (74%) of the 19 marital relationships ( Conclusion: High rate of HTLV-1 intrafamilial transmission was identified in this study. Sexual and vertical transmission are important to familiar dissemination and perpetuation of the virus in this endemic area of the Brazilian Amazon.

Indexed as

AmazonHTLV-1intrafamilial transmissionvertical transmission

Identifiers

PMID41472717
PMCPMC12747787

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.