Evidence map›Paper›PMID 41472687›Full record

ArticleResearch square2025

Hematological Consequences of Environmental Change During Dewilding of Rhesus Macaques.

Annabelle Smith, Kasalina Kiwanuka, Gabriela Pessenda, Andrew R Rahmberg, Jacob K Flynn, Richard Herbert, Jason M Brenchley, P'ng Loke

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Annabelle SmithType 2 Immunity Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, Maryland, USA.
Kasalina KiwanukaType 2 Immunity Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, Maryland, USA.
Gabriela PessendaType 2 Immunity Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, Maryland, USA.
Andrew R RahmbergBarrier Immunity Section, Lab of Viral Diseases, NIAID, NIH, Bethesda, Maryland, USA.ORCID 0000-0002-6306-4584
Jacob K FlynnBarrier Immunity Section, Lab of Viral Diseases, NIAID, NIH, Bethesda, Maryland, USA.
Richard HerbertComparative Medicine Branch, NIAID, NIH, Bethesda, Maryland, USA.
Jason M BrenchleyBarrier Immunity Section, Lab of Viral Diseases, NIAID, NIH, Bethesda, Maryland, USA.
P'ng LokeType 2 Immunity Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, Maryland, USA.ORCID 0000-0002-6211-3292

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The environment shapes immune system development and the regulation of inflammatory responses, which may affect the prevalence of immune mediated inflammatory diseases. However, the hematological consequences of a major environmental change, such as those experienced during migration, remain poorly understood. Here, we used cellular and molecular approaches to assess the immunological consequences in rhesus macaques as they transitioned from an outdoor provisioned environment to an indoor laboratory facility in a process we term 'dewilding.' Dewilding led to a sharp decrease in neutrophils and increased lymphocytes in the peripheral blood, a skewing toward a proinflammatory T

Identifiers

PMID41472687
PMCPMC12747276

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.