Evidence map›Paper›PMID 41472685›Full record

ArticleResearch square2025

β-III tubulin identifies anti-fibrotic state of pericytes in pulmonary fibrosis.

Ryo Sato, Kosuke Imamura, Tatsuya Tsukui, Teruhiko Yoshida, Yusuke Tomita, Kosuke Fujino, Tokunori Ikeda, Keigo Onizawa, Takumi Sogo, Christian A Combs and 7 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Ryo SatoLaboratory of Stem Cell and Neurovascular Research, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, USA.
Kosuke ImamuraDepartment of Respiratory Medicine, Kumamoto University Hospital, Kumamoto, Japan.
Tatsuya TsukuiDivision of Pulmonary, Critical Care, Allergy and Sleep, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0003-3100-6934
Teruhiko YoshidaKidney Disease Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, MD, USA.
Yusuke TomitaDepartment of Respiratory Medicine, Kumamoto University Hospital, Kumamoto, Japan.ORCID 0000-0002-9680-7559
Kosuke FujinoDepartment of Thoracic Surgery, Kumamoto University Hospital, Kumamoto, Japan.
Tokunori IkedaLaboratory of Clinical Pharmacology and Therapeutics, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan.
Keigo OnizawaLaboratory of Stem Cell and Neurovascular Research, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0009-0006-3872-3003
Takumi SogoLaboratory of Stem Cell and Neurovascular Research, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, USA.
Christian A CombsLight Microscopy Core, NHLBI, NIH, Bethesda, MD, USA.
Meera MurgaiLaboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.ORCID 0000-0001-5015-839X
Jeffrey B KoppKidney Disease Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, MD, USA.ORCID 0000-0001-9052-186X
Paul J WoltersDivision of Pulmonary, Critical Care, Allergy and Sleep, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-3108-6164
Makoto SuzukiDepartment of Thoracic Surgery, Kumamoto University Hospital, Kumamoto, Japan.
Takuro SakagamiDepartment of Respiratory Medicine, Kumamoto University Hospital, Kumamoto, Japan.
Dean SheppardDivision of Pulmonary, Critical Care, Allergy and Sleep, Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.ORCID 0000-0002-6277-2036
Yoh-Suke MukouyamaLaboratory of Stem Cell and Neurovascular Research, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD, USA.ORCID 0000-0002-9084-4922

Funding

The study of stem cell and neuro-vascular developmentZ01HL005702 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI MUKOYAMA, YOSUKE · 2006 to 2008
$3.6M
Intramural NIH HHS Z01 HL005702
6 · The paper itself

Abstract

Pericytes have been implicated in pulmonary fibrosis, yet their activated cellular states and functional roles remain largely unclear. Here, we identified β-III tubulin (Tuj1) as a distinctive marker for fibrosis-associated lung pericytes. Most pericytes in fibrotic regions are Tuj1-positive and interact uniquely with multiple endothelial cells, localizing near collagen-producing fibroblasts and pro-fibrotic SPP1

Identifiers

PMID41472685
PMCPMC12747291

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.