ArticleResearch square2025
Single-cell mapping of maternal-fetal cross-talk in preeclampsia.
Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
17 authors.
Funding
Abstract
Preeclampsia (PE) arises from placental dysfunction, yet the cellular events that distinguish early-onset PE (EOPE) from late-onset PE (LOPE) are poorly defined. We generated a comprehensive single-cell atlas of the placenta of women with and without PE (78 patients), integrating maternal-fetal genotyping, multi-dimensional clustering, and cell-cell communication analysis. PE reshaped the abundance and transcriptional states of major placental cell types. EOPE was defined by expanded T and NK cells with reduced extravillous trophoblasts, whereas LOPE involved increased monocytes/macrophages and activation of ANNEXIN-, NOTCH-, ANGPTL-, and EGF-associated pathways. These onset-specific disruptions reveal distinct modes of immune-trophoblast dysregulation. Extending these insights to maternal circulation, multiple EOPE- and LOPE-derived placental mRNA signatures distinguished EOPE from controls at or after diagnosis, and an EOPE-derived CTB-1 protein signature showed moderate predictive value for LOPE. This atlas defines the cellular architecture of PE subtypes and establishes a foundation for developing early, noninvasive biomarkers.
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Registered trials
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