Evidence map›Paper›PMID 41472677›Full record

ArticleResearch square2025

Developmental Dopamine Loss Rewires Striatal Circuits to Promote Locomotion.

Jie Dong, Breanna T Sullivan, Victor M Martinez Smith, Lupeng Wang, Lulu Tian, Justin Kung, Bin Song, Shirong Lin, Andreanna Le, Lixin Sun and 5 more

Abstract readPreprint
In one paragraph

Article in Research square, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Jie DongNational Institutes of Health.
Breanna T SullivanNational Institutes of Health.
Victor M Martinez SmithNational Institutes of Health.
Lupeng WangNational Institutes of Health.
Lulu TianNational Institutes of Health.
Justin KungNational Institutes of Health.
Bin SongNational Institutes of Health.
Shirong LinNational Institutes of Health.
Andreanna LeNational Institutes of Health.
Lixin SunNational Institutes of Health.
Lisa ChangNational Institutes of Health.
Jinhui DingNational Institutes of Health.
Weidong LeZhejiang University School of Medicine.
Jun JiaNational Institutes of Health.
Huaibin CaiNational Institutes of Health.

Funding

Molecular and Pathophysiological Study of Parkinson's DiseaseZIAAG000928 · NIA · NATIONAL INSTITUTE ON AGING · PI CAI, HUAIBIN · 2011 to 2025
$15.8M
Intramural NIH HHS ZIA AG000928
6 · The paper itself

Abstract

Background: Motor symptoms of Parkinson's disease (PD) primarily result from the degeneration of nigrostriatal dopaminergic neurons (DANs), particularly the Aldehyde Dehydrogenase 1A1-positive (ALDH1A1 Methods: We combined RNAscope Results: Conclusions: Our findings reveal a selective reorganization of patch SPNs in response to developmental loss of ALDH1A1

Indexed as

ALDH1A1direct-pathwaydopaminergic neuronsindirect-pathwayKremen1neuromodulationoptogeneticsParkinson’s diseasePitx3striatal projection neurons

Identifiers

PMID41472677
PMCPMC12747274

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.