ArticleMagnetic resonance in medicine2026
Magnetic Properties of Ferritin at Different Levels of Degradation: Implications for MRI-Based Iron Quantification in the Brain.
Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeFerritin's iron core exhibits complex magnetic properties, as suggested by magnetometry and Mössbauer spectroscopy, which remain incompletely understood. In particular, the antiferromagnetic inner core could influence the accuracy of iron quantification using MRI and raise concerns about postmortem validation studies involving degraded ferritin cores.
methodsFresh postmortem brain samples from six deceased human subjects were analyzed using energy-filtered transmission electron microscopy (EFTEM) and electron energy loss spectrometry in scanning mode of the TEM (STEM-EELS) to visualize and quantify the iron cores of ferritin proteins and estimate their iron content. EFTEM findings were compared with results from mass spectrometry and R
resultsAutolysis led to a rapid degradation of ferritin molecules, with fewer than one-third remaining detectable via EFTEM 24 h postmortem. The degradation followed a single-exponential decay pattern, suggesting that almost the entire non-heme iron is stored in ferritin. However, R
conclusionR
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