Evidence map›Paper›PMID 41472529›Full record

ArticleJournal of the American Chemical Society2026

Potent Racemic Antimicrobial Polypeptides Uncovered by a Stereochemical Series of Cationic d/l Backbones.

Swagatam Barman, Alimi Abiodun, Adam Parris, Xiaoming Yang, Md Waliullah Hossain, Prakash Nagarkatti, Mitzi Nagarkatti, Alan W Decho, Chuanbing Tang

Erratum issuedAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Swagatam BarmanDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.ORCID 0009-0007-7277-8945
Alimi AbiodunDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.
Adam ParrisDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.
Xiaoming YangDepartment of Pathology, Microbiology and Immunology, University of South Carolina, School of Medicine, Columbia, South Carolina 29209, United States.
Md Waliullah HossainDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.
Prakash NagarkattiDepartment of Pathology, Microbiology and Immunology, University of South Carolina, School of Medicine, Columbia, South Carolina 29209, United States.
Mitzi NagarkattiDepartment of Pathology, Microbiology and Immunology, University of South Carolina, School of Medicine, Columbia, South Carolina 29209, United States.
Alan W DechoDepartment of Environmental Health Sciences, University of South Carolina, Columbia, South Carolina 29208, United States.
Chuanbing TangDepartment of Chemistry and Biochemistry, University of South Carolina, Columbia, South Carolina 29208, United States.ORCID 0000-0002-0242-8241

Funding

Engineering Cationic Metallopolymers to Potentiate Antibiotics via Multiple MechanismsR01EB038047 · NIBIB · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI Chuanbing Tang · 2025 to 2026
$1.1M
NIBIB NIH HHS R01 EB038047
6 · The paper itself

Abstract

Antimicrobial polypeptides (AMPs) are often engineered to adopt a secondary structure (e.g., α-helix, β-sheet, or turns), reinforcing the prevailing view that ordered conformations are preferred for enhanced activity. Here, we report a first-of-its-kind stereochemical series of cationic polypeptides with defined d/L ratios (100%L, 100%d, 80%d/20%L, 50%d/50%L, 20%d/80%L) via

Indexed as

Anti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesCationsGram-Negative BacteriaGram-Positive BacteriaMicrobial Sensitivity TestsStereoisomerismAnti-Bacterial AgentsAntimicrobial Cationic PeptidesAntimicrobial PeptidesCations

Identifiers

PMID41472529
PMCPMC13130095

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.