Evidence map›Paper›PMID 41472420›Full record

ArticleJournal of biological rhythms2026

Rhythmicity of TOR (Target of Rapamycin) Activity Supports Circadian Function in

Golnoush Akhtari, Milad Falahat Chian, Ethan Myles Sooklal, Patricia Lakin-Thomas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biological rhythms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Golnoush AkhtariDepartment of Biology, York University, Toronto, ON, Canada.
Milad Falahat ChianDepartment of Biology, York University, Toronto, ON, Canada.
Ethan Myles SooklalDepartment of Biology, York University, Toronto, ON, Canada.
Patricia Lakin-ThomasDepartment of Biology, York University, Toronto, ON, Canada.ORCID 0000-0002-0545-9561

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circadian (24 h) rhythmicity is a nearly-ubiquitous property of eukaryotic cells, and the mechanisms that generate this rhythmicity have been studied in a number of organisms for many years. However, there are still gaps in our understanding of the generation and regulation of rhythms. Although transcription/translation feedback loops (TTFLs) are said to be essential to generating rhythmicity in eukaryotes, there are many examples of rhythmicity seen in organisms without functioning TTFLs. Our lab previously found that two genes that function in the TOR (Target of Rapamycin) pathway,

Indexed as

Circadian RhythmFungal ProteinsNeurospora crassaTOR Serine-Threonine KinasesFeedback, PhysiologicalGene Expression Regulation, FungalMutationSpores, FungalFRQ protein, Neurospora crassaFungal ProteinsTOR Serine-Threonine KinasescircadianNeurosporaoscillatorsRPS6target of rapamycin

Identifiers

PMID41472420
PMCPMC12966361

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.