Evidence map›Paper›PMID 41472393›Full record

ArticleHistory of psychiatry2026

Malaria therapy for neurosyphilis at Mont Park Hospital for the insane in Australia, 1927-1928.

Alison Clayton

Abstract readHistorical Article
In one paragraph

Article in History of psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Alison ClaytonUniversity of Melbourne, Parkville, VIC, Australia.ORCID 0000-0002-3634-234X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A century ago, malaria therapy for general paralysis of the insane was a celebrated Nobel Prize-winning psychiatric treatment widely used across the globe. However, in recent years, its legacy has come under increasing scrutiny, with some historians and physicians questioning the claims of it being an effective treatment. This paper, utilizing published accounts and medical record archives, describes malaria therapy for neurosyphilis as conducted by psychiatrist, Reginald Ellery at Victoria's Mont Park Hospital for the Insane, 1927-1928. It also evaluates Ellery's claims about malaria therapy's effectiveness. This research delineates several clinical and research-related factors - such as diagnostic drift, adjunct interventions, and healthy-patient selection - that likely contributed to an overestimation of malaria therapy's effectiveness. Additionally, it demonstrates that patient outcomes as reported in the medical records are notably less positive than described by Ellery in his published accounts. Consequentially, the findings of this study do not support the claims of malaria being an effective treatment for neurosyphilis.

Indexed as

NeurosyphilisAustraliaHistory, 20th CenturyHospitals, PsychiatricHumansgeneral paralysis of the insanehistory of psychiatrymalaria therapyneurosyphilisReginald Ellery

Identifiers

PMID41472393
PMCPMC13237213

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.