Evidence map›Paper›PMID 41472359›Full record

ArticleInternational journal of cancer2026

Conditional survival in glioblastoma: The evolution of prognostic factors over time.

Timothy Mueller, Flavio Vasella, Julia Velz, Stefanos Voglis, Kevin Akeret, Luis Padevit, Morton Schubert, Jonathan Weller, Sarah Brüningk, Elisabeth Rushing and 10 more

Abstract read
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In one paragraph

Article in International journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Timothy MuellerDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland.ORCID https://orcid.org/0000-0002-4702-7142
Flavio VasellaDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland.
Julia VelzDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland.
Stefanos VoglisDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland.
Kevin AkeretDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland.
Luis PadevitDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland.
Morton SchubertDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland.
Jonathan WellerDepartment of Neurosurgery, LMU University Hospital, München, LMU Munich, Germany.ORCID https://orcid.org/0000-0001-6013-8069
Sarah BrüningkDepartment of Radiation Oncology, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Elisabeth RushingDepartment of Neuropathology, University Hospital of Zurich, Zurich, Switzerland.
Johannes SarntheinDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland.
Dorothee GramatzkiDepartment of Neurology, Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland.
Levin HäniDepartment of Neurosurgery, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Andreas RaabeDepartment of Neurosurgery, Inselspital, Bern University Hospital and University of Bern, Bern, Switzerland.
Anna M ZeitlbergerDepartment of Neurosurgery, Cantonal Hospital St.Gallen, HOCH Health Ostschweiz, St. Gallen, Switzerland.
Oliver BozinovDepartment of Neurosurgery, Cantonal Hospital St.Gallen, HOCH Health Ostschweiz, St. Gallen, Switzerland.
Emilie Le RhunDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland.
Michael WellerDepartment of Neurology, Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland.
Luca RegliDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland.
Marian C NeidertDepartment of Neurosurgery, Clinical Neuroscience Center, University Hospital and University of Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conditional survival provides insights into the evolution of prognosis over time and reveals changing associations of prognostic factors during disease progression. Data on the temporal evolution of prognostic factors in glioblastoma remain scarce. We analyzed 315 patients with IDH-wildtype glioblastoma from a prospectively collected registry (01/2008-06/2017). Our primary outcome was 12-month conditional survival (CS), defined as the probability of surviving the next 12 months given survival for "s" months. This analysis was conducted at five landmarks (s = 0, 6, 12, 18, 24) for baseline prognostic factors, including tumor volume compartments. 12-month conditional survival estimates at s = 0, 6, 12, 18, and 24 months from diagnosis were 0.51 (95% CI 0.45-0.56), 0.46 (95% CI 0.39-0.52), 0.41 (95% CI 0.33-0.49), 0.43 (95% CI 0.33-0.52), and 0.56 (95% CI 0.42-0.67), respectively. At diagnosis (s = 0), 12-month survival estimates varied significantly with age >60 at diagnosis, preoperative tumor rim volume >20 cm

Indexed as

Brain NeoplasmsGlioblastomaAdultAgedAged, 80 and overDisease ProgressionDNA MethylationDNA Modification MethylasesDNA Repair EnzymesFemaleHumansMaleMiddle AgedPrognosisProspective StudiesRegistriesDNA Modification MethylasesDNA Repair EnzymesMGMT protein, humanTumor Suppressor Proteinshigh‐grade gliomalandmark analysislong‐term survivaltumor volume

Identifiers

PMID41472359
PMCPMC12996738

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.