Evidence map›Paper›PMID 41472308›Full record

ArticleViruses2025

Antiviral and Immunomodulatory Effects of 7-Deaza-2-methyladenosine (7DMA) in a Susceptible Mouse Model of Usutu Virus Infection.

Rebeca P F Rocha, Marina A Fontoura, Fabrício Naciuk, Leonardo C Oliveira, Alice Nagai, Amanda Bellini Silva, Alexandre Borin, Jaqueline S Felipe, Marjorie Bruder, Lais D Coimbra and 1 more

Abstract read
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rebeca P F RochaBrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP 13083-100, Brazil.ORCID 0000-0002-5678-4006
Marina A FontouraBrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP 13083-100, Brazil.ORCID 0000-0002-1192-7210
Fabrício NaciukBrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP 13083-100, Brazil.ORCID 0000-0001-9176-8821
Leonardo C OliveiraBrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP 13083-100, Brazil.
Alice NagaiBrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP 13083-100, Brazil.ORCID 0000-0002-1267-4569
Amanda Bellini SilvaBrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP 13083-100, Brazil.ORCID 0000-0002-8956-3103
Alexandre BorinBrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP 13083-100, Brazil.
Jaqueline S FelipeBrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP 13083-100, Brazil.
Marjorie BruderBrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP 13083-100, Brazil.ORCID 0000-0003-4236-848X
Lais D CoimbraBrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP 13083-100, Brazil.
Rafael Elias MarquesBrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP 13083-100, Brazil.ORCID 0000-0002-6949-0947

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/10990-1, 2021/05519-0, 2018/02594-9, 2019/0645, 2022/02278-5, 2022/01379-2Ministry of Science, Technology and Innovation PCVENational Council for Scientific and Technological Development Research fellow for REM, INCT-One, INCT-DenguePew Charitable Trusts Scholarship for RPFR
6 · The paper itself

Abstract

Usutu virus (USUV) is an emerging arbovirus recently associated with outbreaks in Western Europe. Although USUV is typically associated with asymptomatic or nonspecific febrile disease, the occurrence of severe neuroinvasive forms of disease has raised concern. There is currently no antiviral treatment available for USUV infection; therefore, we sought to investigate the protective effects of the nucleoside analogue 7DMA against USUV. Adding to 7DMA's activity against USUV in vitro reported by us and others, we found that 7DMA inhibits USUV replication at multiple stages in mammalian cell lines Vero CCL81 and SH-SY5Y. In vivo testing of 7DMA using the susceptible IFNAR

Indexed as

AdenosineAntiviral AgentsFlavivirusFlavivirus InfectionsImmunologic FactorsTubercidinAnimalsChlorocebus aethiopsDisease Models, AnimalFemaleHumansMiceMice, Inbred C57BLMice, KnockoutReceptor, Interferon alpha-betaVero CellsAdenosineAntiviral AgentsImmunologic FactorsReceptor, Interferon alpha-betaTubercidin7DMAantiviralimmunopathogenesismouse modelUsutu virus

Identifiers

PMID41472308
PMCPMC12737359

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.