Evidence map›Paper›PMID 41472304›Full record

ReviewViruses2025

Context-Specific Diversity of Antimicrobial Functions of Interferon-Stimulated Genes.

Munesh K Harioudh, Saumendra N Sarkar

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Munesh K HarioudhProgram in Oncology, Marlene & Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0003-2921-8604
Saumendra N SarkarProgram in Oncology, Marlene & Stewart Greenebaum Comprehensive Cancer Center, University of Maryland School of Medicine, Baltimore, MD 21201, USA.ORCID 0000-0002-2850-6121

Funding

A new mechanism of antiviral activity of 2’-5’ Oligoadenylate Synthetase 1R01AI150214 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DIAMOND, MICHAEL S, SARKAR, SAUMENDRA N · 2020 to 2024
$2.6M
New roles of IFN-inducible OAS proteins in innate immune defense against bacterial infectionsR01AI176333 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Vijay Rathinam, Saumendra N Sarkar · 2023 to 2026
$2.5M
NIAID NIH HHS R01 AI150214NIAID NIH HHS R01 AI176333NIH HHS AI150214, AI176333
6 · The paper itself

Abstract

Interferon-stimulated genes (ISGs) were initially discovered for their role in antiviral functions. However, recent studies show evidence of a diverse and context-specific regulatory function of these genes in antiviral and antibacterial protection. The molecular mechanisms of such activities vary depending on the pathogen, cell type, isoform, and species. In this review, we summarize the context-specific functions of several prominent and well-known ISG families, including OAS, IFITs, ISG15, viperin, ADAR1, and Mx proteins. We provide examples of distinct enzymatic or regulatory mechanisms that are employed by these ISGs to carry out their diverse functions, including nucleic acid sensing, RNA degradation, translation inhibition, membrane remodeling, etc.

Indexed as

InterferonsAnimalsGene Expression RegulationHost-Pathogen InteractionsHumansImmunity, InnateRNA-Binding ProteinsVirusesInterferonsRNA-Binding Proteinsantiviral mechanismInterferoninterferon-stimulated genesoligoadenylate synthetasevirus

Identifiers

PMID41472304
PMCPMC12737575

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.