Evidence map›Paper›PMID 41472287›Full record

ArticleViruses2025

An Attenuated Recombinant Newcastle Disease Virus of Genotype VII Generated by Reverse Genetics.

Hongze Pang, Yidan Bo, Jiawei Chen, Yongzhi Xue, Baishi Lei, Kuan Zhao, Yu Huang, Wenming Jiang, Wuchao Zhang, Wanzhe Yuan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hongze PangCollege of Veterinary Medicine, Hebei Agricultural University, Baoding 071001, China.ORCID 0009-0009-2804-1668
Yidan BoCollege of Veterinary Medicine, Hebei Agricultural University, Baoding 071001, China.
Jiawei ChenCollege of Veterinary Medicine, Hebei Agricultural University, Baoding 071001, China.
Yongzhi XueCollege of Veterinary Medicine, Hebei Agricultural University, Baoding 071001, China.
Baishi LeiCollege of Veterinary Medicine, Hebei Agricultural University, Baoding 071001, China.
Kuan ZhaoCollege of Veterinary Medicine, Hebei Agricultural University, Baoding 071001, China.
Yu HuangFujian Key Laboratory for Prevention and Control of Avian Diseases, Institute of Animal Husbandry and Veterinary Medicine, Fujian Academy of Agricultural Sciences, Fuzhou 350000, China.
Wenming JiangNational Reference Laboratory for Newcastle Disease, China Animal Health and Epidemiology Center, Qingdao 266000, China.
Wuchao ZhangCollege of Veterinary Medicine, Hebei Agricultural University, Baoding 071001, China.
Wanzhe YuanCollege of Veterinary Medicine, Hebei Agricultural University, Baoding 071001, China.

Funding

Fujian Academy of Agricultural Sciences FKADL-2023-02Hebei Provincial Department of Human Resources and Social Security A20221003
6 · The paper itself

Abstract

Genotype VII Newcastle disease virus (NDV) has been confirmed as the predominant epidemic strain in China. Traditional vaccine strains fail to provide complete immune protection when challenged with an epidemic strain. NDV vaccines with phylogenetic relationships closer to those of the endemic viruses demonstrate improved protective efficacy in reducing viral shedding and transmission. This research seeks to develop attenuated vaccine strains that are specifically aligned with NDV genotype VII. A reverse genetics system for the genotype VII NDV HB strain was developed, successfully rescuing the attenuated recombinant virus aHB by substituting the fusion protein (F) cleavage site motif "

Indexed as

Newcastle DiseaseNewcastle disease virusPoultry DiseasesViral VaccinesAnimalsChick EmbryoChickensDNA, RecombinantReverse GeneticsVaccines, AttenuatedDNA, RecombinantVaccines, AttenuatedViral Vaccinesattenuatedgenotype VIInewcastle disease virusreverse geneticsvaccine candidate

Identifiers

PMID41472287
PMCPMC12737340

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.