Evidence map›Paper›PMID 41472220›Full record

ReviewViruses2025

Molecular Aspects of the Emergence of Monkeypox Virus Clades.

Igor V Babkin, Irina N Babkina, Nina V Tikunova

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Igor V BabkinLaboratory of Molecular Microbiology, Institute of Chemical Biology and Fundamental Medicine Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.
Irina N BabkinaAO Vector-Best, Novosibirsk 630117, Russia.
Nina V TikunovaLaboratory of Molecular Microbiology, Institute of Chemical Biology and Fundamental Medicine Siberian Branch of the Russian Academy of Sciences, Novosibirsk 630090, Russia.

Funding

Russian state-funded project 125012300671-8
6 · The paper itself

Abstract

Monkeypox virus (MPXV), which previously caused mainly zoonotic infections, is currently the causative agent of the mpox outbreak that began in 2022. Since the mpox outbreak is characterized by sustained human-to-human transmission, the evolutionary trajectory of MPXV is an important scientific issue. The prevailing hypothesis suggests that the modern orthopoxviruses originated from cowpox-like ancestors with larger genomes that infected a wide range of hosts. Subsequent evolution included the reduction of the genome and the accumulation of substitutions in key proteins. Molecular dating of MPXV evolution revealed 5-6-fold acceleration in the evolutionary rate that was observed in subclade IIb after 2018, reaching 1.8 × 10

Indexed as

Evolution, MolecularMonkeypox virusMpox, MonkeypoxAnimalsGenome, ViralHost SpecificityHumansImmune EvasionMutationPhylogenyViral ProteinsViral Proteinsadaptive selectionevolutionmonkeypox virusmpoxmutation accumulation rateoriginorthopoxvirus

Identifiers

PMID41472220
PMCPMC12737503

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.