Evidence map›Paper›PMID 41472207›Full record

ArticleViruses2025

Generation and Characterization of a CE1-Modified mCherry-Expressing Influenza A Virus for In Vivo Imaging and Antiviral Drug Evaluation.

Zhenghao Li, Meiyi Liu, Jia Yang, Qihui Sun, Dongxue Ye, Wanhui Zhou, Ruikun Du, Shijuan Cheng, Rong Rong, Yong Yang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zhenghao LiInnovative Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Meiyi LiuInnovative Institute of Chinese Medicine and Pharmacy, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Jia YangExperimental Center, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Qihui SunKey Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Dongxue YeExperimental Center, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Wanhui ZhouTraditional Chinese Medicine Research Institute, Shandong Wohua Pharmaceutical Technology Co., Ltd., Weifang 261205, China.
Ruikun DuQingdao Academy of Chinese Medical Sciences, Shandong University of Traditional Chinese Medicine, Qingdao 266122, China.ORCID 0000-0002-9172-7824
Shijuan ChengTraditional Chinese Medicine Research Institute, Shandong Wohua Pharmaceutical Technology Co., Ltd., Weifang 261205, China.
Rong RongKey Laboratory of Traditional Chinese Medicine Classical Theory, Ministry of Education, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Yong YangExperimental Center, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.
Xiaoyun LiuExperimental Center, Shandong University of Traditional Chinese Medicine, Jinan 250355, China.

Funding

China Postdoctoral Science Foundation 2025M773975Key Discipline Construction Project of High-level Traditional Chinese Medicine by National Administration of Traditional Chinese Medicine ZYYZDXK-2023119National Natural Science Foundation of China 82274397, 82505208, 82574901Shandong Postdoctoral Science Foundation SDCX-ZG-202503079Shandong Province Technological Innovation Guidance Program YDZX2023044Shandong University of Traditional Chinese Medicine Research Fund KY2024Z04the 2023 Annual Jinan City-University Integration Development Strategy Project JNSX2023054
6 · The paper itself

Abstract

Influenza reporter viruses are essential for studying viral infection dynamics and assessing antiviral drug efficacy. However, insertion of exogenous reporter genes can impair both viral replication and reporter expression, limiting the development of these systems. In this study, CE1 compensatory mutation

Indexed as

Antiviral AgentsInfluenza A virusInfluenza A Virus, H1N1 SubtypeLuminescent ProteinsAnimalsDogsDrug Evaluation, PreclinicalFemaleGenes, ReporterHumansMadin Darby Canine Kidney CellsMiceMice, Inbred BALB COrthomyxoviridae InfectionsRed Fluorescent ProteinViral Nonstructural ProteinsAntiviral AgentsLuminescent ProteinsRed Fluorescent ProteinViral Nonstructural Proteinsantiviral efficacy assessmentCE1 mutationinfluenza A virusin vivo imagingmCherry expression

Identifiers

PMID41472207
PMCPMC12737787

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.