Evidence map›Paper›PMID 41472206›Full record

ArticleViruses2025

Inactivation of Influenza A Viruses (H1N1, H5N1) During Grana-Type Raw Milk Cheesemaking: Implications for Foodborne Transmission Risk.

Ana Moreno, Stefano Pongolini, Giuseppe Merialdi, Giovanni Cattoli, Calogero Terregino, Nicola Santini, Stefano Benedetti, Luisa Loli Piccolomini, Anna Padovani, Alfonso Rosamilia and 2 more

Abstract read
In one paragraph

Article in Viruses, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ana MorenoIstituto Zooprofilattico Sperimentale of Lombardy and Emilia-Romagna, Via Bianchi 9, 25124 Brescia, Italy.ORCID 0000-0002-8497-9708
Stefano PongoliniIstituto Zooprofilattico Sperimentale of Lombardy and Emilia-Romagna, Via Bianchi 9, 25124 Brescia, Italy.
Giuseppe MerialdiIstituto Zooprofilattico Sperimentale of Lombardy and Emilia-Romagna, Via Bianchi 9, 25124 Brescia, Italy.
Giovanni CattoliIstituto Zooprofilattico Sperimentale delle Venezie, Viale dell'Università 10, 35020 Legnaro, Italy.
Calogero TerreginoIstituto Zooprofilattico Sperimentale delle Venezie, Viale dell'Università 10, 35020 Legnaro, Italy.
Nicola SantiniMinistry of Health, Via Giorgio Ribotta, 5, 00144 Rome, Italy.
Stefano BenedettiRegione Emilia-Romagna, Settore Prevenzione Collettiva and Sanità Pubblica, Viale Aldo Moro 21, 40127 Bologna, Italy.
Luisa Loli PiccolominiRegione Emilia-Romagna, Settore Prevenzione Collettiva and Sanità Pubblica, Viale Aldo Moro 21, 40127 Bologna, Italy.
Anna PadovaniRegione Emilia-Romagna, Settore Prevenzione Collettiva and Sanità Pubblica, Viale Aldo Moro 21, 40127 Bologna, Italy.
Alfonso RosamiliaIstituto Zooprofilattico Sperimentale of Lombardy and Emilia-Romagna, Via Bianchi 9, 25124 Brescia, Italy.ORCID 0000-0003-1042-9268
Giovanni Loris AlboraliIstituto Zooprofilattico Sperimentale of Lombardy and Emilia-Romagna, Via Bianchi 9, 25124 Brescia, Italy.ORCID 0000-0002-4693-6395
Paolo DaminelliIstituto Zooprofilattico Sperimentale of Lombardy and Emilia-Romagna, Via Bianchi 9, 25124 Brescia, Italy.ORCID 0000-0002-3431-5962

Funding

NextGeneration EU-MUR PNRR Extended Partnership initiative on Emerging Infectious Diseases Project no. PE00000007, INF-ACT
6 · The paper itself

Abstract

The detection of H5N1 highly pathogenic avian influenza virus (HPAIV) in lactating dairy cattle in the United States, with high viral titers in raw milk, has raised concerns about zoonotic transmission through unpasteurized milk and dairy products. While viral inactivation during pasteurization is documented, data on persistence in raw-milk cheeses remain limited. This study evaluated the survival of avian influenza viruses (AIVs), both low pathogenic (LPAIV, H1N1) and highly pathogenic (HPAIV, H5N1), during the production and ripening of Grana-type hard cheeses from raw cow's milk. Experimental cheesemaking was carried out with milk artificially contaminated with A/duck/Italy/281904-2/06 (H1N1; 10

Indexed as

CheeseFoodborne DiseasesInfluenza A virusRaw FoodsVirus InactivationFood HandlingInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H5N1 SubtypeMilkcheesemakingfood safetyGrana-type raw milk cheeseH5N1 HPAIV clade 2.3.4.4bhighly pathogenic and low pathogenic avian influenza viruspasteurizationviral persistencevirus inactivation

Identifiers

PMID41472206
PMCPMC12737345

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.