ReviewVeterinary sciences2025
Inflammation in the Transition Period of Dairy Cows: New Paradigms.
Review in Veterinary sciences, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- The Combination of Phytogenic in High-Starch Diets for Growing Cattle and Its Effects on Immunomodulation, Fermentation, Microbiota, and Performance.Animals : an open access journal from MDPI · 2026Article
- Pro-inflammatory cytokines as indicators of health status around calving in dairy cows.Veterinary and animal science · 2026Article
- Effect of the Use of Bovine Appeasing Substance on Immunological, Metabolic, and Oxidative Parameters of Postpartum Dairy Cows: Modulation of the Stress Axis.Animals : an open access journal from MDPI · 2026Article
- Latent inflammatory activity is associated with alterations in iron bioavailability during early postpartum adaptation in dairy cows.Frontiers in veterinary science · 2026Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
By analyzing new findings from the literature on immunometabolism during the transition period, as well as classical concepts, we aim to propose a new approach to the inflammation paradigm in cows transitioning from gestation to lactation. The purpose of this review, based on data from scientific articles and reviews, is to characterize the immunometabolism of the transition period, highlighting the main characteristics of the inflammatory response in dairy cows and listing the mechanisms that govern inflammatory tone and coordinate the resolution of inflammation, with a view of new paradigms and analysis of non-classical pathways. We also seek to analyze inflammation and the role of mitochondria and the endoplasmic reticulum in the genesis of diseases, proposing approaches for modulating inflammatory tone. This review analyzes the classical theoretical approach using mechanistic views anchored in knowledge produced in other species and based on new evidence from the bovine field, determining new paradigms. This study highlights the constant inflammatory condition during the transition period and its effect on metabolism and demonstrates the role of dysregulation of inflammation resolution as a central factor in the genesis of diseases. Purinergic and cholinergic anti-inflammatory pathways have been little explored in cattle, but it is believed that the role of these pathways in maintaining homeostasis represents a great opportunity for understanding and modulating the phenomenon of inflammation in dairy cows. Dysregulation of the stress axis shows elucidative potential regarding the dysregulation of inflammatory resolution, with mitochondrial health and endoplasmic reticulum stress being dividing factors between homeorhetic and pathological states. Modulating inflammation and establishing inflammatory resolution presents challenges with classic anti-inflammatory drugs due to the paradoxical role of prostaglandin E2 in inflammation and resolution. Phytoactives offer new possibilities for modulating inflammation without disrupting inflammatory resolution and ensuring antioxidant effects, associated with strategies for formulating less inflammatory diets.
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Registered trials
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