Evidence map›Paper›PMID 41471908›Full record

ArticleMicroorganisms2025

Epstein-Barr Virus Silences GSDME and Pyroptosis in Gastric Cancer.

Min-Hyeok Lee, Ju Yeon Lee, Jun Yeob Kim, Yea Rim An, Suk Kyeong Lee

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Min-Hyeok LeeDepartment of Medical Life Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.ORCID 0009-0007-8179-0110
Ju Yeon LeeDepartment of Medical Life Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.ORCID 0009-0008-1620-9980
Jun Yeob KimDepartment of Medical Life Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.ORCID 0009-0008-5794-7875
Yea Rim AnDepartment of Medical Life Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.ORCID 0009-0007-8318-0404
Suk Kyeong LeeDepartment of Medical Life Sciences, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.ORCID 0000-0002-3751-7682

Funding

National Research Foundation of Korea NRF-2021R1A2C1006571The Catholic University of Korea Catholic Medical Center The authors wish to acknowledge the financial support of the Catholic Medical Center Research Foundation made in the program year of 2025.
6 · The paper itself

Abstract

Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) represents a distinct molecular subtype characterized by extensive DNA methylation and altered cell death signaling. This study investigated the regulation and function of gasdermin E (GSDME), a key mediator of pyroptosis, in EBVaGC. Transcriptomic analysis of The Cancer Genome Atlas (TCGA) data revealed that

Indexed as

caspase-3DNA methylationepigenetic regulationEpstein–Barr virusgastric cancerGSDMEpaclitaxelpyroptosis

Identifiers

PMID41471908
PMCPMC12735423

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.