Evidence map›Paper›PMID 41471873›Full record

ArticleMicroorganisms2025

Decoding the Gut Microbiome in Primary Sjögren's Syndrome and Primary Biliary Cholangitis: Shared Dysbiosis, Distinct Patterns, and Associations with Clinical Features.

Bo Zang, Lishan Xu, Haojie Huang, Qixuan Liu, Yuan Yao, Jiaxiu Li, Yifei Yang, Chenyang Zhao, Bingqian Liu, Bin Liu

Abstract read
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bo ZangDepartment of Rheumatology, Affiliated Hospital of Qingdao University, Qingdao 266001, China.ORCID 0000-0001-7534-8595
Lishan XuDepartment of Rheumatology, Liaocheng People's Hospital, Liaocheng 252003, China.
Haojie HuangState Key Laboratory of Microbial Technology, Shandong University, Qingdao 266299, China.ORCID 0000-0001-6546-3741
Qixuan LiuGraduate Group of Epidemiology, School of Veterinary Medicine, University of California, Davis, CA 95616, USA.
Yuan YaoDepartment of Rheumatology, Affiliated Hospital of Qingdao University, Qingdao 266001, China.
Jiaxiu LiDepartment of Rheumatology, Affiliated Hospital of Qingdao University, Qingdao 266001, China.
Yifei YangDepartment of Rheumatology, Affiliated Hospital of Qingdao University, Qingdao 266001, China.
Chenyang ZhaoDepartment of Internal Medicine II, Heart Center Bonn, University Hospital Bonn, 53127 Bonn, Germany.
Bingqian LiuDepartment of Rheumatology, Affiliated Hospital of Qingdao University, Qingdao 266001, China.
Bin LiuDepartment of Rheumatology, Affiliated Hospital of Qingdao University, Qingdao 266001, China.

Funding

National Natural Science Foundation of China 81241094National Natural Science Foundation of China 81671600Natural Science Foundation of Shandong Province ZR2016HM13 /ZR2023MH066Qingdao Medical and health scientific research project 2024-WJKY160
6 · The paper itself

Abstract

This study aimed to analyze gut microbiome similarities and differences between primary biliary cholangitis (PBC) and primary Sjögren's syndrome (pSS), exploring potential associations with disease pathogenesis. High-throughput sequencing of the 16S rRNA gene was performed on fecal samples from 100 subjects (PBC: 38; pSS: 42; HC: 20) to compare the composition, diversity, and key microbial markers, examining associations with clinical indicators. The gut microbiome of PBC and pSS patients exhibited reduced alpha diversity (

Indexed as

16S rRNA gene sequencingclinical indicatorsgut microbiomekey microbial markerprimary biliary cholangitisprimary Sjögren’s syndrome

Identifiers

PMID41471873
PMCPMC12734952

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.