Evidence map›Paper›PMID 41471870›Full record

ArticleMicroorganisms2025

Identification and Characterization of Three Novel B-Cell Epitopes in African Swine Fever Virus p22 Protein.

Zehui Li, Jingming Zhou, Yumei Chen, Hongliang Liu, Yanhua Qi, Chao Liang, Xifang Zhu, Enping Liu, Sixuan Wu, Peiyang Ding and 1 more

Abstract read
In one paragraph

Article in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zehui LiLonghu Laboratory of Advanced Immunology, Zhengzhou 450046, China.
Jingming ZhouLonghu Laboratory of Advanced Immunology, Zhengzhou 450046, China.
Yumei ChenLonghu Laboratory of Advanced Immunology, Zhengzhou 450046, China.
Hongliang LiuHenan Provincial Key Laboratory of Immunological Biology, Zhengzhou 450001, China.
Yanhua QiHenan Provincial Key Laboratory of Immunological Biology, Zhengzhou 450001, China.
Chao LiangLonghu Laboratory of Advanced Immunology, Zhengzhou 450046, China.
Xifang ZhuHenan Provincial Key Laboratory of Immunological Biology, Zhengzhou 450001, China.
Enping LiuHenan Provincial Key Laboratory of Immunological Biology, Zhengzhou 450001, China.ORCID 0009-0005-2605-6314
Sixuan WuHenan Provincial Key Laboratory of Immunological Biology, Zhengzhou 450001, China.
Peiyang DingHenan Provincial Key Laboratory of Immunological Biology, Zhengzhou 450001, China.ORCID 0000-0001-6332-8597
Aiping WangLonghu Laboratory of Advanced Immunology, Zhengzhou 450046, China.ORCID 0000-0003-1661-8174

Funding

Key scientific research projects of colleges and universities in Henan province 24A230018Major Science and Technology Projects in Henan Province 241110310200Major Science and Technology Projects of Henan Province 221100110600Special Project on Key Research and Promotion of Henan Province 242102111017
6 · The paper itself

Abstract

African swine fever virus (ASFV) is a highly contagious pathogen causing African swine fever in wild boars, warthogs and domestic pigs. The disease leads tosubstantial economic losses to the global pork industry and poses a grave threat to biodiversity. The early-encoded structural protein p22, owing to its immunodominant characteristics and high conservation across most genotypes, represents a promising diagnostic target and subunit vaccine candidate. In this study, the soluble extracellular domain of p22 protein (aa 30-177) was successfully expressed and purified, yielding 1.220 g/L. Eleven strains of monoclonal antibodies against p22 were generated, with four selected for B-cell epitope screening. Bioinformatic prediction-guided design was employed to generate overlapping truncations and peptides for epitope mapping. Based on those strategies, three novel linear B-cell epitopes were identified to be

Indexed as

African swine fever virus p22conservation analysismonoclonal antibodiesnovel B-cell epitopesrecombinant expression

Identifiers

PMID41471870
PMCPMC12735792

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.