ArticleMicroorganisms2025
Gut Microbiota Profiling by 16S rRNA Sequencing in Children with Mild or Intermittent Asthma: A Pilot Study in Alessandria, Italy.
Valentina Pizzo, Alessia Francese, Paolo Bottino, Carlotta Bertolina, Franca Gotta, Michela Gandino, Enrico Felici, Riccardo Mazzucco, Marinella Bertolotti, Annalisa Roveta and 2 more
Abstract read
In one paragraphArticle in Microorganisms, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
12 authors.
Valentina PizzoMicrobiology and Virology Laboratory, Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy.
Alessia FranceseResearch Laboratories, Research and Innovation Department, Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy.ORCID 0000-0001-5999-6111 Paolo BottinoMicrobiology and Virology Laboratory, Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy.ORCID 0000-0002-6337-5729 Carlotta BertolinaResearch Training Innovation Infrastructure, Research and Innovation Department, Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy.ORCID 0000-0001-5458-6914 Franca GottaMicrobiology and Virology Laboratory, Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy.ORCID 0009-0006-2200-2674 Michela GandinoPediatric and Pediatric Emergency Unit, Children Hospital, Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy.
Enrico FeliciPediatric and Pediatric Emergency Unit, Children Hospital, Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy.
Riccardo MazzuccoResearch and Innovation Department, Azienda Sanitaria Locale, 15121 Alessandria, Italy.ORCID 0009-0008-8266-4359 Marinella BertolottiResearch Training Innovation Infrastructure, Research and Innovation Department, Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy.
Annalisa RovetaResearch Laboratories, Research and Innovation Department, Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy.ORCID 0000-0003-2484-0963 Andrea RocchettiMicrobiology and Virology Laboratory, Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy.ORCID 0000-0002-6259-5295 Antonio MaconiResearch Training Innovation Infrastructure, Research and Innovation Department, Azienda Ospedaliero-Universitaria SS. Antonio e Biagio e Cesare Arrigo, 15121 Alessandria, Italy.ORCID 0000-0002-1904-7277 Funding
Riccoboni Holding 15.000€
6 · The paper itselfAbstract
Asthma is one of the most common chronic diseases in childhood, and the gut microbiota is increasingly recognized as a key player in its pathogenesis through the gut-lung axis. This pilot, cross-sectional study analyzed the intestinal microbiota of 20 children (6-9 years) with intermittent or mild persistent asthma, in the absence of a healthy control group. Stool samples were processed with 16S rRNA sequencing (Illumina iSeq100, V3-V6 regions) and analyzed with MicrobAT-SmartSeq software. Contrary to most literature, no enrichment of
Indexed as
dysbiosisgut microbiotaiSeq sequencingmediterranean dietpediatric asthma
Identifiers
PMID41471868
PMCPMC12735130
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LicenceCC BY
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